Serological response and persistence in schoolchildren with high baseline seropositive rate after receiving 2009 pandemic influenza A(H1N1) vaccine

Day Yu Chao, Kuang Fu Cheng, Ying Hen Hsieh, Tsai Chung Li, Trong Neng Wu, Chiu Ying Chen, Chen An Tsai, Jin Hwa Chen, Hsien Tsai Chiu, Jang Jih Lu, Mei Chi Su, Yu Hsin Liao

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8 Citations (Scopus)

Abstract

The serological response of the current 2009 H1N1 pandemic influenza monovalent vaccine in children exhibiting high baseline seropositive rate was evaluated though a community-based household study. Seroprotection rate of >90% and seroconversion rate of >50% were observed in children one month after receiving the pandemic vaccine. Among children with low baseline antibody titer, a significant lower seroconversion rate (55%) was observed in children who received seasonal trivalent inactivated vaccine (TIV) prior to pandemic vaccine, when compared with those receiving the pandemic vaccine only (86%). Persistence of antibody against the pandemic influenza virus was observed 6 months after vaccination in >80% of children presenting seroprotective antibody levels.

Original languageEnglish
Pages (from-to)617-623
Number of pages7
JournalVaccine
Volume29
Issue number4
DOIs
Publication statusPublished - Jan 17 2011
Externally publishedYes

Keywords

  • 2009 pH1N1
  • Immune response
  • Pandemic influenza
  • Schoolchildren
  • Serology
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

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  • Cite this

    Chao, D. Y., Cheng, K. F., Hsieh, Y. H., Li, T. C., Wu, T. N., Chen, C. Y., Tsai, C. A., Chen, J. H., Chiu, H. T., Lu, J. J., Su, M. C., & Liao, Y. H. (2011). Serological response and persistence in schoolchildren with high baseline seropositive rate after receiving 2009 pandemic influenza A(H1N1) vaccine. Vaccine, 29(4), 617-623. https://doi.org/10.1016/j.vaccine.2010.11.016