Serologic assessment of the risk of developing chronic Q fever in cohorts of acutely infected individuals

Min Nan Hung, Li Jen Lin, Min Yi Hou, Po Shan Lin, Yung Chun Wang, Pei Yun Shu, Chien Chou Lin, Hsiu Ying Lu, Yung Ching Liu

Research output: Contribution to journalArticle

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Abstract

Objective: The aim of this study was to assess the clinical significance of serological profiles suggestive of chronic Q fever after acute infection. Methods: A prospective follow-up study consisting of two separate cohorts was conducted to monitor the serological evolution of Q fever. The first cohort comprised subjects with acute Q fever diagnosed in 2004-2007 and the second enrolled subjects whose infection occurred in 2009. The indirect immunofluorescence assay was used for serological monitoring, with serum PCR testing added for subjects whose serological profiles revealed high titers of anti-phase I IgG ≥ 800, titers suggestive of chronic Q fever. Results: In the first cohort of 92 persons, seventeen (18%) subjects had serological profiles suggestive of chronic Q fever (titers of anti-phase I IgG: 1280-5120, median: 1280) after a median follow-up period of 606.5 days. After a further follow-up (median period: 592 days) exclusively for those seventeen subjects, serological resolution with fourfold decrease of titers of anti-phase I IgG was noted in five of them. In the second cohort, only one (4%) of the twenty-eight subjects had high levels of anti-phase I IgG 180 days after acute infection. All the eighteen subjects with high levels of anti-phase I IgG were asymptomatic and had negative serum PCR testing. The different prevalence of subjects with high titers of anti-phase I IgG in the two cohorts was associated with duration of follow-up period (P <.01). Conclusions: Subjects with high titers of anti-phase I IgG ≥ 800 was not uncommon and might not be detected until more than six months after acute Q fever infection. Asymptomatic subjects with high levels of anti-phase I IgG alone should not be treated as chronic Q fever and might not need continued serological monitoring in the absence of predisposing factors to chronic Q fever.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalJournal of Infection
Volume62
Issue number1
DOIs
Publication statusPublished - Jan 2011

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Q Fever
Immunoglobulin G
Infection
Polymerase Chain Reaction
Indirect Fluorescent Antibody Technique
Serum
Causality

Keywords

  • Cohort studies
  • Coxiella burnetii
  • Follow-up studies
  • Q fever

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Serologic assessment of the risk of developing chronic Q fever in cohorts of acutely infected individuals. / Hung, Min Nan; Lin, Li Jen; Hou, Min Yi; Lin, Po Shan; Wang, Yung Chun; Shu, Pei Yun; Lin, Chien Chou; Lu, Hsiu Ying; Liu, Yung Ching.

In: Journal of Infection, Vol. 62, No. 1, 01.2011, p. 39-44.

Research output: Contribution to journalArticle

Hung, Min Nan ; Lin, Li Jen ; Hou, Min Yi ; Lin, Po Shan ; Wang, Yung Chun ; Shu, Pei Yun ; Lin, Chien Chou ; Lu, Hsiu Ying ; Liu, Yung Ching. / Serologic assessment of the risk of developing chronic Q fever in cohorts of acutely infected individuals. In: Journal of Infection. 2011 ; Vol. 62, No. 1. pp. 39-44.
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abstract = "Objective: The aim of this study was to assess the clinical significance of serological profiles suggestive of chronic Q fever after acute infection. Methods: A prospective follow-up study consisting of two separate cohorts was conducted to monitor the serological evolution of Q fever. The first cohort comprised subjects with acute Q fever diagnosed in 2004-2007 and the second enrolled subjects whose infection occurred in 2009. The indirect immunofluorescence assay was used for serological monitoring, with serum PCR testing added for subjects whose serological profiles revealed high titers of anti-phase I IgG ≥ 800, titers suggestive of chronic Q fever. Results: In the first cohort of 92 persons, seventeen (18{\%}) subjects had serological profiles suggestive of chronic Q fever (titers of anti-phase I IgG: 1280-5120, median: 1280) after a median follow-up period of 606.5 days. After a further follow-up (median period: 592 days) exclusively for those seventeen subjects, serological resolution with fourfold decrease of titers of anti-phase I IgG was noted in five of them. In the second cohort, only one (4{\%}) of the twenty-eight subjects had high levels of anti-phase I IgG 180 days after acute infection. All the eighteen subjects with high levels of anti-phase I IgG were asymptomatic and had negative serum PCR testing. The different prevalence of subjects with high titers of anti-phase I IgG in the two cohorts was associated with duration of follow-up period (P <.01). Conclusions: Subjects with high titers of anti-phase I IgG ≥ 800 was not uncommon and might not be detected until more than six months after acute Q fever infection. Asymptomatic subjects with high levels of anti-phase I IgG alone should not be treated as chronic Q fever and might not need continued serological monitoring in the absence of predisposing factors to chronic Q fever.",
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T1 - Serologic assessment of the risk of developing chronic Q fever in cohorts of acutely infected individuals

AU - Hung, Min Nan

AU - Lin, Li Jen

AU - Hou, Min Yi

AU - Lin, Po Shan

AU - Wang, Yung Chun

AU - Shu, Pei Yun

AU - Lin, Chien Chou

AU - Lu, Hsiu Ying

AU - Liu, Yung Ching

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N2 - Objective: The aim of this study was to assess the clinical significance of serological profiles suggestive of chronic Q fever after acute infection. Methods: A prospective follow-up study consisting of two separate cohorts was conducted to monitor the serological evolution of Q fever. The first cohort comprised subjects with acute Q fever diagnosed in 2004-2007 and the second enrolled subjects whose infection occurred in 2009. The indirect immunofluorescence assay was used for serological monitoring, with serum PCR testing added for subjects whose serological profiles revealed high titers of anti-phase I IgG ≥ 800, titers suggestive of chronic Q fever. Results: In the first cohort of 92 persons, seventeen (18%) subjects had serological profiles suggestive of chronic Q fever (titers of anti-phase I IgG: 1280-5120, median: 1280) after a median follow-up period of 606.5 days. After a further follow-up (median period: 592 days) exclusively for those seventeen subjects, serological resolution with fourfold decrease of titers of anti-phase I IgG was noted in five of them. In the second cohort, only one (4%) of the twenty-eight subjects had high levels of anti-phase I IgG 180 days after acute infection. All the eighteen subjects with high levels of anti-phase I IgG were asymptomatic and had negative serum PCR testing. The different prevalence of subjects with high titers of anti-phase I IgG in the two cohorts was associated with duration of follow-up period (P <.01). Conclusions: Subjects with high titers of anti-phase I IgG ≥ 800 was not uncommon and might not be detected until more than six months after acute Q fever infection. Asymptomatic subjects with high levels of anti-phase I IgG alone should not be treated as chronic Q fever and might not need continued serological monitoring in the absence of predisposing factors to chronic Q fever.

AB - Objective: The aim of this study was to assess the clinical significance of serological profiles suggestive of chronic Q fever after acute infection. Methods: A prospective follow-up study consisting of two separate cohorts was conducted to monitor the serological evolution of Q fever. The first cohort comprised subjects with acute Q fever diagnosed in 2004-2007 and the second enrolled subjects whose infection occurred in 2009. The indirect immunofluorescence assay was used for serological monitoring, with serum PCR testing added for subjects whose serological profiles revealed high titers of anti-phase I IgG ≥ 800, titers suggestive of chronic Q fever. Results: In the first cohort of 92 persons, seventeen (18%) subjects had serological profiles suggestive of chronic Q fever (titers of anti-phase I IgG: 1280-5120, median: 1280) after a median follow-up period of 606.5 days. After a further follow-up (median period: 592 days) exclusively for those seventeen subjects, serological resolution with fourfold decrease of titers of anti-phase I IgG was noted in five of them. In the second cohort, only one (4%) of the twenty-eight subjects had high levels of anti-phase I IgG 180 days after acute infection. All the eighteen subjects with high levels of anti-phase I IgG were asymptomatic and had negative serum PCR testing. The different prevalence of subjects with high titers of anti-phase I IgG in the two cohorts was associated with duration of follow-up period (P <.01). Conclusions: Subjects with high titers of anti-phase I IgG ≥ 800 was not uncommon and might not be detected until more than six months after acute Q fever infection. Asymptomatic subjects with high levels of anti-phase I IgG alone should not be treated as chronic Q fever and might not need continued serological monitoring in the absence of predisposing factors to chronic Q fever.

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KW - Coxiella burnetii

KW - Follow-up studies

KW - Q fever

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