Serial magnetic resonance imaging in patients with Balo's concentric sclerosis

Natural history of lesion development

Chi Jen Chen, Nai Shin Chu, Chin Song Lu, Chung Yang Sung

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

We reviewed the magnetic resonance imaging scans from 22 serial studies of 5 patients with Balo's concentric sclerosis collected during the past 3 years. The data showed the concentric lesions did not occur simultaneously but developed step by step in a centrifugal direction. The development of lesions was preceded by an enhancing ring relatively devoid of demyelination and was followed by progressive demyelination occurring mainly at the inner aspect of the enhancement. The same process recurred on the edge of the previous enhanced zone. Thus, an appearance of concentric rings with alternating demyelinated and relatively myelin-preserved bands was formed.

Original languageEnglish
Pages (from-to)651-656
Number of pages6
JournalAnnals of Neurology
Volume46
Issue number4
DOIs
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Diffuse Cerebral Sclerosis of Schilder
Demyelinating Diseases
Natural History
Magnetic Resonance Imaging
Myelin Sheath

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Serial magnetic resonance imaging in patients with Balo's concentric sclerosis : Natural history of lesion development. / Chen, Chi Jen; Chu, Nai Shin; Lu, Chin Song; Sung, Chung Yang.

In: Annals of Neurology, Vol. 46, No. 4, 1999, p. 651-656.

Research output: Contribution to journalArticle

@article{cc65c77b288d4ff5b28873ac7ecba529,
title = "Serial magnetic resonance imaging in patients with Balo's concentric sclerosis: Natural history of lesion development",
abstract = "We reviewed the magnetic resonance imaging scans from 22 serial studies of 5 patients with Balo's concentric sclerosis collected during the past 3 years. The data showed the concentric lesions did not occur simultaneously but developed step by step in a centrifugal direction. The development of lesions was preceded by an enhancing ring relatively devoid of demyelination and was followed by progressive demyelination occurring mainly at the inner aspect of the enhancement. The same process recurred on the edge of the previous enhanced zone. Thus, an appearance of concentric rings with alternating demyelinated and relatively myelin-preserved bands was formed.",
author = "Chen, {Chi Jen} and Chu, {Nai Shin} and Lu, {Chin Song} and Sung, {Chung Yang}",
year = "1999",
doi = "10.1002/1531-8249(199910)46:4<651::AID-ANA15>3.0.CO;2-Y",
language = "English",
volume = "46",
pages = "651--656",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Serial magnetic resonance imaging in patients with Balo's concentric sclerosis

T2 - Natural history of lesion development

AU - Chen, Chi Jen

AU - Chu, Nai Shin

AU - Lu, Chin Song

AU - Sung, Chung Yang

PY - 1999

Y1 - 1999

N2 - We reviewed the magnetic resonance imaging scans from 22 serial studies of 5 patients with Balo's concentric sclerosis collected during the past 3 years. The data showed the concentric lesions did not occur simultaneously but developed step by step in a centrifugal direction. The development of lesions was preceded by an enhancing ring relatively devoid of demyelination and was followed by progressive demyelination occurring mainly at the inner aspect of the enhancement. The same process recurred on the edge of the previous enhanced zone. Thus, an appearance of concentric rings with alternating demyelinated and relatively myelin-preserved bands was formed.

AB - We reviewed the magnetic resonance imaging scans from 22 serial studies of 5 patients with Balo's concentric sclerosis collected during the past 3 years. The data showed the concentric lesions did not occur simultaneously but developed step by step in a centrifugal direction. The development of lesions was preceded by an enhancing ring relatively devoid of demyelination and was followed by progressive demyelination occurring mainly at the inner aspect of the enhancement. The same process recurred on the edge of the previous enhanced zone. Thus, an appearance of concentric rings with alternating demyelinated and relatively myelin-preserved bands was formed.

UR - http://www.scopus.com/inward/record.url?scp=0032831010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032831010&partnerID=8YFLogxK

U2 - 10.1002/1531-8249(199910)46:4<651::AID-ANA15>3.0.CO;2-Y

DO - 10.1002/1531-8249(199910)46:4<651::AID-ANA15>3.0.CO;2-Y

M3 - Article

VL - 46

SP - 651

EP - 656

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 4

ER -