Serial changes in plasma annexin A1 and cortisol levels in sepsis patients

Wen Hui Tsai, I. Ting Li, Yuan Bin Yu, Hui Chi Hsu, Chung Hung Shih

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Annexin A1 (AnxA1), originally identified as a glucocorticoid-regulated protein, is an important endogenous anti-inflammatory mediator during the resolution phase of inflammation, and its circulating level has been rarely studied in sepsis patients. Glucocorticoid has been extensively used in treating patients with sepsis. However, it is unclear whether endogenous cortisol or exogenous glucocorticoid contributes to the regulation of AnxA1 levels in peripheral blood of sepsis patients. The aim of this study was to investigate: [1] serial changes over time in the plasma levels of AnxA1 and cortisol in sepsis patients; and [2] prognostic value of AnxA1 level in the survival of sepsis patients. Fifty-eight adult sepsis patients admitted to an intensive care unit (ICU) were enrolled. The plasma levels of cortisol and AnxA1 were determined by specific enzyme-link immunosorbent assay. Results show that the median daily levels of cortisol at the 1st, 3rd, 5th and 7th day after admission to ICU were significantly elevated over the cortisol level of the control subjects. However, the AnxA1 level was elevated in only thirty-three patients (56%) over the observation period. There was no significant correlation between cortisol levels and AnxA1 levels. Further analysis indicated that steroid treatment resulted in significant elevation of the cortisol level over time, but did not affect the AnxA1 level. AnxA1 levels were also not statistically different between surviving and non-surviving patients. In conclusions, the circulating level of AnxA1 is elevated in a subgroup of sepsis patients, and the AnxA1 level does not correlate with the cortisol level in the peripheral blood of sepsis patients.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalChinese Journal of Physiology
Volume57
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Annexin A1
Annexins
Hydrocortisone
Sepsis
Glucocorticoids
Intensive Care Units
Immunosorbents
Anti-Inflammatory Agents
Steroids
Observation

Keywords

  • Acute lung injury
  • Annexin A1
  • Anti-inflammatory mediators
  • Cortisol
  • Sepsis

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Serial changes in plasma annexin A1 and cortisol levels in sepsis patients. / Tsai, Wen Hui; Li, I. Ting; Yu, Yuan Bin; Hsu, Hui Chi; Shih, Chung Hung.

In: Chinese Journal of Physiology, Vol. 57, No. 1, 2014, p. 1-7.

Research output: Contribution to journalArticle

Tsai, Wen Hui ; Li, I. Ting ; Yu, Yuan Bin ; Hsu, Hui Chi ; Shih, Chung Hung. / Serial changes in plasma annexin A1 and cortisol levels in sepsis patients. In: Chinese Journal of Physiology. 2014 ; Vol. 57, No. 1. pp. 1-7.
@article{2b1afb739053449588d4144612d4fddb,
title = "Serial changes in plasma annexin A1 and cortisol levels in sepsis patients",
abstract = "Annexin A1 (AnxA1), originally identified as a glucocorticoid-regulated protein, is an important endogenous anti-inflammatory mediator during the resolution phase of inflammation, and its circulating level has been rarely studied in sepsis patients. Glucocorticoid has been extensively used in treating patients with sepsis. However, it is unclear whether endogenous cortisol or exogenous glucocorticoid contributes to the regulation of AnxA1 levels in peripheral blood of sepsis patients. The aim of this study was to investigate: [1] serial changes over time in the plasma levels of AnxA1 and cortisol in sepsis patients; and [2] prognostic value of AnxA1 level in the survival of sepsis patients. Fifty-eight adult sepsis patients admitted to an intensive care unit (ICU) were enrolled. The plasma levels of cortisol and AnxA1 were determined by specific enzyme-link immunosorbent assay. Results show that the median daily levels of cortisol at the 1st, 3rd, 5th and 7th day after admission to ICU were significantly elevated over the cortisol level of the control subjects. However, the AnxA1 level was elevated in only thirty-three patients (56{\%}) over the observation period. There was no significant correlation between cortisol levels and AnxA1 levels. Further analysis indicated that steroid treatment resulted in significant elevation of the cortisol level over time, but did not affect the AnxA1 level. AnxA1 levels were also not statistically different between surviving and non-surviving patients. In conclusions, the circulating level of AnxA1 is elevated in a subgroup of sepsis patients, and the AnxA1 level does not correlate with the cortisol level in the peripheral blood of sepsis patients.",
keywords = "Acute lung injury, Annexin A1, Anti-inflammatory mediators, Cortisol, Sepsis",
author = "Tsai, {Wen Hui} and Li, {I. Ting} and Yu, {Yuan Bin} and Hsu, {Hui Chi} and Shih, {Chung Hung}",
year = "2014",
doi = "10.4077/CJP.2014.BAB193",
language = "English",
volume = "57",
pages = "1--7",
journal = "Chinese Journal of Physiology",
issn = "0304-4920",
publisher = "Chinese Physiological Society",
number = "1",

}

TY - JOUR

T1 - Serial changes in plasma annexin A1 and cortisol levels in sepsis patients

AU - Tsai, Wen Hui

AU - Li, I. Ting

AU - Yu, Yuan Bin

AU - Hsu, Hui Chi

AU - Shih, Chung Hung

PY - 2014

Y1 - 2014

N2 - Annexin A1 (AnxA1), originally identified as a glucocorticoid-regulated protein, is an important endogenous anti-inflammatory mediator during the resolution phase of inflammation, and its circulating level has been rarely studied in sepsis patients. Glucocorticoid has been extensively used in treating patients with sepsis. However, it is unclear whether endogenous cortisol or exogenous glucocorticoid contributes to the regulation of AnxA1 levels in peripheral blood of sepsis patients. The aim of this study was to investigate: [1] serial changes over time in the plasma levels of AnxA1 and cortisol in sepsis patients; and [2] prognostic value of AnxA1 level in the survival of sepsis patients. Fifty-eight adult sepsis patients admitted to an intensive care unit (ICU) were enrolled. The plasma levels of cortisol and AnxA1 were determined by specific enzyme-link immunosorbent assay. Results show that the median daily levels of cortisol at the 1st, 3rd, 5th and 7th day after admission to ICU were significantly elevated over the cortisol level of the control subjects. However, the AnxA1 level was elevated in only thirty-three patients (56%) over the observation period. There was no significant correlation between cortisol levels and AnxA1 levels. Further analysis indicated that steroid treatment resulted in significant elevation of the cortisol level over time, but did not affect the AnxA1 level. AnxA1 levels were also not statistically different between surviving and non-surviving patients. In conclusions, the circulating level of AnxA1 is elevated in a subgroup of sepsis patients, and the AnxA1 level does not correlate with the cortisol level in the peripheral blood of sepsis patients.

AB - Annexin A1 (AnxA1), originally identified as a glucocorticoid-regulated protein, is an important endogenous anti-inflammatory mediator during the resolution phase of inflammation, and its circulating level has been rarely studied in sepsis patients. Glucocorticoid has been extensively used in treating patients with sepsis. However, it is unclear whether endogenous cortisol or exogenous glucocorticoid contributes to the regulation of AnxA1 levels in peripheral blood of sepsis patients. The aim of this study was to investigate: [1] serial changes over time in the plasma levels of AnxA1 and cortisol in sepsis patients; and [2] prognostic value of AnxA1 level in the survival of sepsis patients. Fifty-eight adult sepsis patients admitted to an intensive care unit (ICU) were enrolled. The plasma levels of cortisol and AnxA1 were determined by specific enzyme-link immunosorbent assay. Results show that the median daily levels of cortisol at the 1st, 3rd, 5th and 7th day after admission to ICU were significantly elevated over the cortisol level of the control subjects. However, the AnxA1 level was elevated in only thirty-three patients (56%) over the observation period. There was no significant correlation between cortisol levels and AnxA1 levels. Further analysis indicated that steroid treatment resulted in significant elevation of the cortisol level over time, but did not affect the AnxA1 level. AnxA1 levels were also not statistically different between surviving and non-surviving patients. In conclusions, the circulating level of AnxA1 is elevated in a subgroup of sepsis patients, and the AnxA1 level does not correlate with the cortisol level in the peripheral blood of sepsis patients.

KW - Acute lung injury

KW - Annexin A1

KW - Anti-inflammatory mediators

KW - Cortisol

KW - Sepsis

UR - http://www.scopus.com/inward/record.url?scp=84904252241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904252241&partnerID=8YFLogxK

U2 - 10.4077/CJP.2014.BAB193

DO - 10.4077/CJP.2014.BAB193

M3 - Article

VL - 57

SP - 1

EP - 7

JO - Chinese Journal of Physiology

JF - Chinese Journal of Physiology

SN - 0304-4920

IS - 1

ER -