Sensitivity of vagal afferent endings to chemical irritants in the rat lung

C. Y. Ho, Q. Gu, Y. S. Lin, L. Y. Lee

Research output: Contribution to journalArticlepeer-review

155 Citations (Scopus)


This study was carried out to investigate the relationship between the conduction velocity of the vagal afferents arising from the rat lungs and their sensitivities to capsaicin, other chemical irritants, and lung inflation. We recorded single-unit activities of vagal pulmonary afferents (n=205) in anesthetized, open-chest rats, and distinguished C fibers (conduction velocity2O) was not only extremely weak, but also showed a longer onset latency and an irregular pattern. In a sharp contrast, lung inflation evoked rapid and vigorous discharges in both RARs and SARs. In conclusion, C fibers are the primary type of chemosensitive vagal pulmonary afferents in rat lungs.

Original languageEnglish
Pages (from-to)113-124
Number of pages12
JournalRespiration Physiology
Issue number2-3
Publication statusPublished - 2001
Externally publishedYes


  • Afferents
  • Capsaicin
  • Conduction velocity
  • Irritants
  • Mammals
  • Rat
  • Sensitivity
  • Sensitivity irritants
  • Vagal
  • Vagus

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

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