Sensitivity of vagal afferent endings to chemical irritants in the rat lung

C. Y. Ho, Q. Gu, Y. S. Lin, L. Y. Lee

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

This study was carried out to investigate the relationship between the conduction velocity of the vagal afferents arising from the rat lungs and their sensitivities to capsaicin, other chemical irritants, and lung inflation. We recorded single-unit activities of vagal pulmonary afferents (n=205) in anesthetized, open-chest rats, and distinguished C fibers (conduction velocity2O) was not only extremely weak, but also showed a longer onset latency and an irregular pattern. In a sharp contrast, lung inflation evoked rapid and vigorous discharges in both RARs and SARs. In conclusion, C fibers are the primary type of chemosensitive vagal pulmonary afferents in rat lungs.

Original languageEnglish
Pages (from-to)113-124
Number of pages12
JournalRespiration Physiology
Volume127
Issue number2-3
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Irritants
Lung
Unmyelinated Nerve Fibers
Economic Inflation
Capsaicin
Thorax

Keywords

  • Afferents
  • Capsaicin
  • Conduction velocity
  • Irritants
  • Mammals
  • Rat
  • Sensitivity
  • Sensitivity irritants
  • Vagal
  • Vagus

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Sensitivity of vagal afferent endings to chemical irritants in the rat lung. / Ho, C. Y.; Gu, Q.; Lin, Y. S.; Lee, L. Y.

In: Respiration Physiology, Vol. 127, No. 2-3, 2001, p. 113-124.

Research output: Contribution to journalArticle

Ho, C. Y. ; Gu, Q. ; Lin, Y. S. ; Lee, L. Y. / Sensitivity of vagal afferent endings to chemical irritants in the rat lung. In: Respiration Physiology. 2001 ; Vol. 127, No. 2-3. pp. 113-124.
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