Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA

Yi Hwa Lin, Show Mei Chuang, Pei Ching Wu, Chun Liang Chen, Sivakamavalli Jeyachandran, Shou Chen Lo, Hsu Shan Huang, Ming Hon Hou

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The development of a ligand that is capable of distinguishing among the wide variety of G-quadruplex structures and targeting telomeres to treat cancer is particularly challenging. In this study, the ability of two anthraquinone telomerase inhibitors (NSC749235 and NSC764638) to target telomeric G-quadruplex DNA was probed. We found that these ligands specifically target the potassium form of telomeric G-quadruplex DNA over the DNA counterpart. The characteristic interaction with the telomeric G-quadruplex DNA and the anticancer activities of these ligands were also explored. The results of this present work emphasize our understanding of the binding selectivity of anthraquinone derivatives to G-quadruplex DNA and assists in future drug development for G-quadruplex-specific ligands.

Original languageEnglish
Article number31019
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - Aug 11 2016

Fingerprint

Potassium
Stabilization
Ligands
DNA
Anthraquinones
Telomerase
Pharmaceutical Preparations

ASJC Scopus subject areas

  • General

Cite this

Lin, Y. H., Chuang, S. M., Wu, P. C., Chen, C. L., Jeyachandran, S., Lo, S. C., ... Hou, M. H. (2016). Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA. Scientific Reports, 6, [31019]. https://doi.org/10.1038/srep31019

Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA. / Lin, Yi Hwa; Chuang, Show Mei; Wu, Pei Ching; Chen, Chun Liang; Jeyachandran, Sivakamavalli; Lo, Shou Chen; Huang, Hsu Shan; Hou, Ming Hon.

In: Scientific Reports, Vol. 6, 31019, 11.08.2016.

Research output: Contribution to journalArticle

Lin, Yi Hwa ; Chuang, Show Mei ; Wu, Pei Ching ; Chen, Chun Liang ; Jeyachandran, Sivakamavalli ; Lo, Shou Chen ; Huang, Hsu Shan ; Hou, Ming Hon. / Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA. In: Scientific Reports. 2016 ; Vol. 6.
@article{31f9f279b83e41cca8418110fe8c7437,
title = "Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA",
abstract = "The development of a ligand that is capable of distinguishing among the wide variety of G-quadruplex structures and targeting telomeres to treat cancer is particularly challenging. In this study, the ability of two anthraquinone telomerase inhibitors (NSC749235 and NSC764638) to target telomeric G-quadruplex DNA was probed. We found that these ligands specifically target the potassium form of telomeric G-quadruplex DNA over the DNA counterpart. The characteristic interaction with the telomeric G-quadruplex DNA and the anticancer activities of these ligands were also explored. The results of this present work emphasize our understanding of the binding selectivity of anthraquinone derivatives to G-quadruplex DNA and assists in future drug development for G-quadruplex-specific ligands.",
author = "Lin, {Yi Hwa} and Chuang, {Show Mei} and Wu, {Pei Ching} and Chen, {Chun Liang} and Sivakamavalli Jeyachandran and Lo, {Shou Chen} and Huang, {Hsu Shan} and Hou, {Ming Hon}",
year = "2016",
month = "8",
day = "11",
doi = "10.1038/srep31019",
language = "English",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA

AU - Lin, Yi Hwa

AU - Chuang, Show Mei

AU - Wu, Pei Ching

AU - Chen, Chun Liang

AU - Jeyachandran, Sivakamavalli

AU - Lo, Shou Chen

AU - Huang, Hsu Shan

AU - Hou, Ming Hon

PY - 2016/8/11

Y1 - 2016/8/11

N2 - The development of a ligand that is capable of distinguishing among the wide variety of G-quadruplex structures and targeting telomeres to treat cancer is particularly challenging. In this study, the ability of two anthraquinone telomerase inhibitors (NSC749235 and NSC764638) to target telomeric G-quadruplex DNA was probed. We found that these ligands specifically target the potassium form of telomeric G-quadruplex DNA over the DNA counterpart. The characteristic interaction with the telomeric G-quadruplex DNA and the anticancer activities of these ligands were also explored. The results of this present work emphasize our understanding of the binding selectivity of anthraquinone derivatives to G-quadruplex DNA and assists in future drug development for G-quadruplex-specific ligands.

AB - The development of a ligand that is capable of distinguishing among the wide variety of G-quadruplex structures and targeting telomeres to treat cancer is particularly challenging. In this study, the ability of two anthraquinone telomerase inhibitors (NSC749235 and NSC764638) to target telomeric G-quadruplex DNA was probed. We found that these ligands specifically target the potassium form of telomeric G-quadruplex DNA over the DNA counterpart. The characteristic interaction with the telomeric G-quadruplex DNA and the anticancer activities of these ligands were also explored. The results of this present work emphasize our understanding of the binding selectivity of anthraquinone derivatives to G-quadruplex DNA and assists in future drug development for G-quadruplex-specific ligands.

UR - http://www.scopus.com/inward/record.url?scp=84982170206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982170206&partnerID=8YFLogxK

U2 - 10.1038/srep31019

DO - 10.1038/srep31019

M3 - Article

AN - SCOPUS:84982170206

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 31019

ER -