Selective laser sintering of a hydroxyapatite-silica scaffold on cultured MG63 osteoblasts in vitro

Fwu Hsing Liu, Yung Kang Shen, Jeou Long Lee

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

This study forms hydroxyapatite-silica ceramic structure, which can generate interconnected porous 3D models suitable as bone scaffold, using a novel selective laser sintering (SLS) technique. Hydroxyapatite (HA) powder and a silica sol are first mixed into slurries. After processing by SLS, the HA particles are embedded in the gelled silica matrix to form green parts. The processed parts are analyzed by scanning electron microscopy (SEM). The number of cells attached on this scaffold surface is obtained by the in vitro cultured cells test. The higher number of viable cells are obtained when the sintering temperature of the scaffold was 1200°C at day 4 of cell culturing. The proposed technology can be applied to generate a bone scaffold model of porous bio-ceramics for biomedicine.

Original languageEnglish
Pages (from-to)439-444
Number of pages6
JournalInternational Journal of Precision Engineering and Manufacturing
Volume13
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • Ceramics
  • Powder processing
  • Scanning electron microscopy (SEM)
  • Sol-gel methods

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Industrial and Manufacturing Engineering
  • Mechanical Engineering

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