Selective IgA deficiency and anaphylactoid transfusion reaction: A case report

Chih Hsin Wei, Marie Lin, Ruey Kuen Hsieh, Cheng Hwai Tzeng, Jin Hwang Liu, Sheng Fan, Tzeon Jye Chiou, Po Min Chen

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Anaphylactoid transfusion reaction following the administration of incompatible blood products can be life threatening, but accounts for only a very small proportion of all transfusion reactions. One of the causes of anaphylactoid transfusion reaction is the reaction of patient's anti-immunoglobulin A(IgA) with plasma IgA which is usually present in transfused blood. We report a case who had anaphylactoid transfusion reactions after transfusion of only a few milliliters of packed RBC from 3 consecutive donors, in spite of compatible pretransfusion crossmatches. The patient's serum revealed IgA deficiency accompanied by high-titer anti-IgA. The family study showed that one of her sons had partial IgA deficiency accompanied by anti-IgA2. In conclusion, although selective IgA deficiency is rare in Taiwan, it may still occasionally result in severe anaphylactoid transfusion reactions.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalChinese Medical Journal (Taipei)
Volume57
Issue number2
Publication statusPublished - Feb 1996
Externally publishedYes

Keywords

  • Anaphylactoid transfusion reaction
  • Selective IgA deficiency

ASJC Scopus subject areas

  • Medicine(all)

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