Segregated neural representation of psychological and somatic-vegetative symptoms in severe major depression

Alexander Heinzel, Simone Grimm, Johannes Beck, Daniel Schuepbach, Daniel Hell, Peter Boesiger, Heinz Boeker, Georg Northoff

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: The Beck Depression Inventory (BDI) is probably the most widely used depression scale. It has been suggested that it contains a two-factor structure measuring cognitive-affective (i.e. psychological) and somatic-vegetative depressive symptoms. In this study we aim to evaluate these factors by probing for their neural correlates. Methods: Neural responses evoked by emotional perception, relative to an emotional judgment task, were measured using functional magnetic resonance imaging (fMRI) in 20 medication-free patients with severe MDD. Psychological and somatic-vegetative symptoms were evaluated with the BDI. Results: Psychological symptoms correlated with signal changes in the dorsomedial and right ventrolateral prefrontal cortex, while somatic-vegetative symptoms correlated with signal changes in the pre-genual anterior cingulate cortex. Conclusions: These preliminary findings demonstrate segregated neural representation of psychological and somatic-vegetative symptoms of MDD in different cortical regions. Thus, our results indicate that the two-factor structure of the BDI is related to distinct neural correlates.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalNeuroscience Letters
Volume456
Issue number2
DOIs
Publication statusPublished - Jun 5 2009

Fingerprint

Depression
Psychology
Equipment and Supplies
Gyrus Cinguli
Prefrontal Cortex
Magnetic Resonance Imaging
Medically Unexplained Symptoms

Keywords

  • Beck Depression Inventory
  • Emotional perception
  • fMRI
  • Major depressive disorder

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Segregated neural representation of psychological and somatic-vegetative symptoms in severe major depression. / Heinzel, Alexander; Grimm, Simone; Beck, Johannes; Schuepbach, Daniel; Hell, Daniel; Boesiger, Peter; Boeker, Heinz; Northoff, Georg.

In: Neuroscience Letters, Vol. 456, No. 2, 05.06.2009, p. 49-53.

Research output: Contribution to journalArticle

Heinzel, Alexander ; Grimm, Simone ; Beck, Johannes ; Schuepbach, Daniel ; Hell, Daniel ; Boesiger, Peter ; Boeker, Heinz ; Northoff, Georg. / Segregated neural representation of psychological and somatic-vegetative symptoms in severe major depression. In: Neuroscience Letters. 2009 ; Vol. 456, No. 2. pp. 49-53.
@article{980de150b27446b8a04664ced1d774e7,
title = "Segregated neural representation of psychological and somatic-vegetative symptoms in severe major depression",
abstract = "Objective: The Beck Depression Inventory (BDI) is probably the most widely used depression scale. It has been suggested that it contains a two-factor structure measuring cognitive-affective (i.e. psychological) and somatic-vegetative depressive symptoms. In this study we aim to evaluate these factors by probing for their neural correlates. Methods: Neural responses evoked by emotional perception, relative to an emotional judgment task, were measured using functional magnetic resonance imaging (fMRI) in 20 medication-free patients with severe MDD. Psychological and somatic-vegetative symptoms were evaluated with the BDI. Results: Psychological symptoms correlated with signal changes in the dorsomedial and right ventrolateral prefrontal cortex, while somatic-vegetative symptoms correlated with signal changes in the pre-genual anterior cingulate cortex. Conclusions: These preliminary findings demonstrate segregated neural representation of psychological and somatic-vegetative symptoms of MDD in different cortical regions. Thus, our results indicate that the two-factor structure of the BDI is related to distinct neural correlates.",
keywords = "Beck Depression Inventory, Emotional perception, fMRI, Major depressive disorder",
author = "Alexander Heinzel and Simone Grimm and Johannes Beck and Daniel Schuepbach and Daniel Hell and Peter Boesiger and Heinz Boeker and Georg Northoff",
year = "2009",
month = "6",
day = "5",
doi = "10.1016/j.neulet.2009.03.097",
language = "English",
volume = "456",
pages = "49--53",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Segregated neural representation of psychological and somatic-vegetative symptoms in severe major depression

AU - Heinzel, Alexander

AU - Grimm, Simone

AU - Beck, Johannes

AU - Schuepbach, Daniel

AU - Hell, Daniel

AU - Boesiger, Peter

AU - Boeker, Heinz

AU - Northoff, Georg

PY - 2009/6/5

Y1 - 2009/6/5

N2 - Objective: The Beck Depression Inventory (BDI) is probably the most widely used depression scale. It has been suggested that it contains a two-factor structure measuring cognitive-affective (i.e. psychological) and somatic-vegetative depressive symptoms. In this study we aim to evaluate these factors by probing for their neural correlates. Methods: Neural responses evoked by emotional perception, relative to an emotional judgment task, were measured using functional magnetic resonance imaging (fMRI) in 20 medication-free patients with severe MDD. Psychological and somatic-vegetative symptoms were evaluated with the BDI. Results: Psychological symptoms correlated with signal changes in the dorsomedial and right ventrolateral prefrontal cortex, while somatic-vegetative symptoms correlated with signal changes in the pre-genual anterior cingulate cortex. Conclusions: These preliminary findings demonstrate segregated neural representation of psychological and somatic-vegetative symptoms of MDD in different cortical regions. Thus, our results indicate that the two-factor structure of the BDI is related to distinct neural correlates.

AB - Objective: The Beck Depression Inventory (BDI) is probably the most widely used depression scale. It has been suggested that it contains a two-factor structure measuring cognitive-affective (i.e. psychological) and somatic-vegetative depressive symptoms. In this study we aim to evaluate these factors by probing for their neural correlates. Methods: Neural responses evoked by emotional perception, relative to an emotional judgment task, were measured using functional magnetic resonance imaging (fMRI) in 20 medication-free patients with severe MDD. Psychological and somatic-vegetative symptoms were evaluated with the BDI. Results: Psychological symptoms correlated with signal changes in the dorsomedial and right ventrolateral prefrontal cortex, while somatic-vegetative symptoms correlated with signal changes in the pre-genual anterior cingulate cortex. Conclusions: These preliminary findings demonstrate segregated neural representation of psychological and somatic-vegetative symptoms of MDD in different cortical regions. Thus, our results indicate that the two-factor structure of the BDI is related to distinct neural correlates.

KW - Beck Depression Inventory

KW - Emotional perception

KW - fMRI

KW - Major depressive disorder

UR - http://www.scopus.com/inward/record.url?scp=64749114652&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64749114652&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2009.03.097

DO - 10.1016/j.neulet.2009.03.097

M3 - Article

C2 - 19429132

AN - SCOPUS:64749114652

VL - 456

SP - 49

EP - 53

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -