Segregated neural representation of psychological and somatic-vegetative symptoms in severe major depression

Alexander Heinzel, Simone Grimm, Johannes Beck, Daniel Schuepbach, Daniel Hell, Peter Boesiger, Heinz Boeker, Georg Northoff

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: The Beck Depression Inventory (BDI) is probably the most widely used depression scale. It has been suggested that it contains a two-factor structure measuring cognitive-affective (i.e. psychological) and somatic-vegetative depressive symptoms. In this study we aim to evaluate these factors by probing for their neural correlates. Methods: Neural responses evoked by emotional perception, relative to an emotional judgment task, were measured using functional magnetic resonance imaging (fMRI) in 20 medication-free patients with severe MDD. Psychological and somatic-vegetative symptoms were evaluated with the BDI. Results: Psychological symptoms correlated with signal changes in the dorsomedial and right ventrolateral prefrontal cortex, while somatic-vegetative symptoms correlated with signal changes in the pre-genual anterior cingulate cortex. Conclusions: These preliminary findings demonstrate segregated neural representation of psychological and somatic-vegetative symptoms of MDD in different cortical regions. Thus, our results indicate that the two-factor structure of the BDI is related to distinct neural correlates.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalNeuroscience Letters
Volume456
Issue number2
DOIs
Publication statusPublished - Jun 5 2009

Keywords

  • Beck Depression Inventory
  • Emotional perception
  • fMRI
  • Major depressive disorder

ASJC Scopus subject areas

  • Neuroscience(all)

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