TY - JOUR
T1 - SEEKING and depression in stroke patients
T2 - An exploratory study
AU - Farinelli, Marina
AU - Panksepp, Jaak
AU - Gestieri, Laura
AU - Leo, Maria Rosaria
AU - Agati, Raffaele
AU - Maffei, Monica
AU - Leonardi, Marco
AU - Northoff, Georg
PY - 2013/4/1
Y1 - 2013/4/1
N2 - The concept of SEEKING describes a predisposition to search enthusiastically for rewards in the environment. While SEEKING and its underlying functional anatomy have been extensively investigated in animals, such processes in humans, especially brain-damaged individuals, remain understudied. We therefore conducted an exploratory behavioral study in stroke patients to investigate the effects of brain lesions that anatomically could be interpreted to impact the SEEKING system and predicted relationships to depression. Patients with lesions in anterior, medial, and/or subcortical lesions showed significantly lower SEEKING scores and higher depression scores than nonlesioned subjects in the control group. Based on our data and related work on animals, we propose central involvement of the anterior subcortical-cortical midline system as core of the limbic system in SEEKING in humans.
AB - The concept of SEEKING describes a predisposition to search enthusiastically for rewards in the environment. While SEEKING and its underlying functional anatomy have been extensively investigated in animals, such processes in humans, especially brain-damaged individuals, remain understudied. We therefore conducted an exploratory behavioral study in stroke patients to investigate the effects of brain lesions that anatomically could be interpreted to impact the SEEKING system and predicted relationships to depression. Patients with lesions in anterior, medial, and/or subcortical lesions showed significantly lower SEEKING scores and higher depression scores than nonlesioned subjects in the control group. Based on our data and related work on animals, we propose central involvement of the anterior subcortical-cortical midline system as core of the limbic system in SEEKING in humans.
KW - Affective neuroscience
KW - Depression
KW - Rehabilitation
KW - SEEKING
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=84876797061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876797061&partnerID=8YFLogxK
U2 - 10.1080/13803395.2013.776009
DO - 10.1080/13803395.2013.776009
M3 - Article
C2 - 23458324
AN - SCOPUS:84876797061
VL - 35
SP - 348
EP - 358
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
SN - 1380-3395
IS - 4
ER -