Secondary metabolites of the endophytic fungus Lachnum abnorme from Ardisia cornudentata

Hsun Shuo Chang, Chu Hung Lin, Yi Shuan Chen, Hui Chun Wang, Hing Yuen Chan, Sung Yuan Hsieh, Ho Cheng Wu, Ming Jen Cheng, Gwo Fang Yuan, Shan Yu Lin, Yue Jin Lin, Ih Sheng Chen

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Fractionation of an EtOAc-soluble fraction of the solid fermentate of an endophytic fungus, Lachnum abnorme Mont. BCRC 09F0006, derived from the endemic plant, Ardisia cornudentata Mez. (Myrsinaceae), resulted in the isolation of three new chromones, lachnochromonins D–F (1–3), one novel compound, lachabnormic acid (4), along with nine known compounds (5–13). Their structures were elucidated by spectroscopic analyses. Alternariol-3,9-dimethyl ether (6) was given the correct data as well as 2D spectral analyses for the first time. This is the first report of the isolation of one unprecedented compound 4 from Lachnum genus, while all known compounds were also found for the first time from Lachnum. The effects of some isolates (3, 4, 7–9, 10, and 13) on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 murine macrophages were also evaluated. Several compounds exhibited weak inhibitory activity on lipopolysaccharide (LPS)-stimulated NO production in RAW 264.7 macrophages.

Original languageEnglish
Article number1512
JournalInternational journal of molecular sciences
Volume17
Issue number9
DOIs
Publication statusPublished - Sep 8 2016
Externally publishedYes

Keywords

  • Anti-inflammatory activity
  • Ardisia cornudentata
  • Lachnum abnorme
  • Myrsinaceae
  • Stem

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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