Secondary metabolites from the stems of Engelhardia roxburghiana and their antitubercular activities

Ho Chen Wu, Ming Jen Cheng, Chien Fang Peng, Shyh Chyun Yang, Hsun Shuo Chang, Chu Hung Lin, Chyi Jia Wang, Ih Sheng Chen

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Bioassay-guided fractionation of stems of Engelhardia roxburghiana led to isolation of: four diarylheptanoids, engelheptanoxides A-D (1-4); two cyclic diarylheptanoids, engelhardiols A (5) and B (6); one naphthoquinone dimer, engelharquinonol (7); and one 1-tetralone, (4S)-4,6-dihydroxy-1-tetralone (8), along with 24 known compounds (9-32). The structures of 1-8 were by spectroscopic analysis. Compounds 5, 6, 13, 22, and 23 showed antitubercular activity against Mycobacterium tuberculosis H37Rv with MIC values of 72.7, 62.1, 9.1, 15.3, and 70.1 μM, respectively.

Original languageEnglish
Pages (from-to)118-127
Number of pages10
JournalPhytochemistry
Volume82
DOIs
Publication statusPublished - Oct 2012
Externally publishedYes

Keywords

  • Antitubercular activity
  • Diarylheptanoid
  • Engelhardia roxburghiana
  • Juglandaceae
  • Naphthoquinone dimer
  • Stem
  • Tetralone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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