Second transplantation from HLA 2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation

Takayuki Tanaka, Hiroshi Matsubara, Souichi Adachi, Hsi Chang, Hisanori Fujino, Yuri Higashi, Takahiro Yasumi, Michihiro Kobayashi, Ken Ichiro Watanabe, Munehisa Takahashi, Yoshiro Kobayashi, Etsuko Maruya, Hiroh Saji, Tatsutoshi Nakahata

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

A 7-year-old girl with acute myelogenous leukemia with multilineage dysplasia received unrelated cord blood transplantation but developed hemophagocytic syndrome (HPS) after sepsis with methicillin-resistant coagulase-negative staphylococci before engraftment. Bone marrow aspiration on day 20 revealed a markedly increased number of activated macrophages showing hemophagocytosis. The presence of donor-type chimera in the bone marrow was confirmed at that time. We therefore quickly started immunosuppressive and antibacterial treatment. Although her condition gradually improved, the patient suffered graft failure due to HPS. She received peripheral blood stem cell transplantation from her HLA 2-loci-mismatched mother on day 54 and continued in complete remission 12 months after the second transplantation. The results in this case suggested that because of fetomaternal microchimerism it may be useful to select an HLA-haploidentical mother as a backup donor for stem cell transplantation.

Original languageEnglish
Pages (from-to)467-469
Number of pages3
JournalInternational Journal of Hematology
Volume80
Issue number5
DOIs
Publication statusPublished - Dec 2004
Externally publishedYes

Keywords

  • Fetomaternal
  • Hemophagocytosis
  • Second transplantation
  • Sepsis

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Second transplantation from HLA 2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation'. Together they form a unique fingerprint.

Cite this