Second transplantation from HLA 2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation

Takayuki Tanaka, Hiroshi Matsubara, Souichi Adachi, Hsi Chang, Hisanori Fujino, Yuri Higashi, Takahiro Yasumi, Michihiro Kobayashi, Ken Ichiro Watanabe, Munehisa Takahashi, Yoshiro Kobayashi, Etsuko Maruya, Hiroh Saji, Tatsutoshi Nakahata

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A 7-year-old girl with acute myelogenous leukemia with multilineage dysplasia received unrelated cord blood transplantation but developed hemophagocytic syndrome (HPS) after sepsis with methicillin-resistant coagulase-negative staphylococci before engraftment. Bone marrow aspiration on day 20 revealed a markedly increased number of activated macrophages showing hemophagocytosis. The presence of donor-type chimera in the bone marrow was confirmed at that time. We therefore quickly started immunosuppressive and antibacterial treatment. Although her condition gradually improved, the patient suffered graft failure due to HPS. She received peripheral blood stem cell transplantation from her HLA 2-loci-mismatched mother on day 54 and continued in complete remission 12 months after the second transplantation. The results in this case suggested that because of fetomaternal microchimerism it may be useful to select an HLA-haploidentical mother as a backup donor for stem cell transplantation.

Original languageEnglish
Pages (from-to)467-469
Number of pages3
JournalInternational Journal of Hematology
Volume80
Issue number5
DOIs
Publication statusPublished - Dec 2004
Externally publishedYes

Fingerprint

Hemophagocytic Lymphohistiocytosis
Fetal Blood
Transplantation
Bone Marrow
Mothers
Tissue Donors
Transplants
Peripheral Blood Stem Cell Transplantation
Chimerism
Methicillin Resistance
Coagulase
Stem Cell Transplantation
Immunosuppressive Agents
Staphylococcus
Acute Myeloid Leukemia
Sepsis
Macrophages
Therapeutics
Aspirations (Psychology)

Keywords

  • Fetomaternal
  • Hemophagocytosis
  • Second transplantation
  • Sepsis

ASJC Scopus subject areas

  • Hematology

Cite this

Second transplantation from HLA 2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation. / Tanaka, Takayuki; Matsubara, Hiroshi; Adachi, Souichi; Chang, Hsi; Fujino, Hisanori; Higashi, Yuri; Yasumi, Takahiro; Kobayashi, Michihiro; Watanabe, Ken Ichiro; Takahashi, Munehisa; Kobayashi, Yoshiro; Maruya, Etsuko; Saji, Hiroh; Nakahata, Tatsutoshi.

In: International Journal of Hematology, Vol. 80, No. 5, 12.2004, p. 467-469.

Research output: Contribution to journalArticle

Tanaka, T, Matsubara, H, Adachi, S, Chang, H, Fujino, H, Higashi, Y, Yasumi, T, Kobayashi, M, Watanabe, KI, Takahashi, M, Kobayashi, Y, Maruya, E, Saji, H & Nakahata, T 2004, 'Second transplantation from HLA 2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation', International Journal of Hematology, vol. 80, no. 5, pp. 467-469. https://doi.org/10.1532/IJH97.04063
Tanaka, Takayuki ; Matsubara, Hiroshi ; Adachi, Souichi ; Chang, Hsi ; Fujino, Hisanori ; Higashi, Yuri ; Yasumi, Takahiro ; Kobayashi, Michihiro ; Watanabe, Ken Ichiro ; Takahashi, Munehisa ; Kobayashi, Yoshiro ; Maruya, Etsuko ; Saji, Hiroh ; Nakahata, Tatsutoshi. / Second transplantation from HLA 2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation. In: International Journal of Hematology. 2004 ; Vol. 80, No. 5. pp. 467-469.
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