Second primary cancers in patients with hepatocellular carcinoma

A nationwide cohort study in Taiwan

Wen Chieh Wu, Yung Tai Chen, Chian Yaw Hwang, Chien Wei Su, Szu Yuan Li, Tzeng Ji Chen, Chia Jen Liu, Wei Yu Kao, Yee Chao, Han Chieh Lin, Jaw Ching Wu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: There has been no large-scale population-based study on the incidence and clinical manifestations of second primary cancer (SPC) after diagnosis of hepatocellular carcinoma (HCC). Aims: This study aimed to evaluate the incidence and the risk factors of SPC following HCC diagnosis. Method: This study used data from the National Health Insurance Research Database of Taiwan to identify all HCC patients from 1 January 1997 to 31 December 2006. Cases of SPC were gathered using the ICD9-CM codes of 140-208.91. Standardized incidence ratios (SIRs) were conducted for incidence of SPC in HCC survivors. Competing-risks regression with adjustment of death was used to analyse the risk factors of SPC. Results: From 45 976 HCC patients, 749 (1.6%) developed SPC after 90 days of HCC diagnosis. Male HCC patients had higher risks of gastric, biliary, urinary bladder, kidney and haematological cancers compared to the general male population. Female patients had higher incidences of biliary tract, kidney and bone and soft tissue cancers. Older age and chronic kidney disease (CKD) were independent factors predicting SPC. Conclusions: SPC in patients with HCC is not rare in Taiwan. Urinary bladder cancer and renal cancer are more specific SPC for HCC patients. Better surveillance strategies for SPC should be established for HCC survivors, especially in the elderly or those with CKD.

Original languageEnglish
Pages (from-to)616-623
Number of pages8
JournalLiver International
Volume33
Issue number4
DOIs
Publication statusPublished - Apr 1 2013
Externally publishedYes

Fingerprint

Second Primary Neoplasms
Taiwan
Hepatocellular Carcinoma
Cohort Studies
Kidney Neoplasms
Incidence
Chronic Renal Insufficiency
Survivors
National Health Programs
Biliary Tract
Urinary Bladder Neoplasms
Population
Stomach
Urinary Bladder
Databases
Kidney
Bone and Bones

Keywords

  • Hepatocellular carcinoma
  • Multiple primary malignancy
  • Second primary cancer

ASJC Scopus subject areas

  • Hepatology

Cite this

Wu, W. C., Chen, Y. T., Hwang, C. Y., Su, C. W., Li, S. Y., Chen, T. J., ... Wu, J. C. (2013). Second primary cancers in patients with hepatocellular carcinoma: A nationwide cohort study in Taiwan. Liver International, 33(4), 616-623. https://doi.org/10.1111/liv.12103

Second primary cancers in patients with hepatocellular carcinoma : A nationwide cohort study in Taiwan. / Wu, Wen Chieh; Chen, Yung Tai; Hwang, Chian Yaw; Su, Chien Wei; Li, Szu Yuan; Chen, Tzeng Ji; Liu, Chia Jen; Kao, Wei Yu; Chao, Yee; Lin, Han Chieh; Wu, Jaw Ching.

In: Liver International, Vol. 33, No. 4, 01.04.2013, p. 616-623.

Research output: Contribution to journalArticle

Wu, WC, Chen, YT, Hwang, CY, Su, CW, Li, SY, Chen, TJ, Liu, CJ, Kao, WY, Chao, Y, Lin, HC & Wu, JC 2013, 'Second primary cancers in patients with hepatocellular carcinoma: A nationwide cohort study in Taiwan', Liver International, vol. 33, no. 4, pp. 616-623. https://doi.org/10.1111/liv.12103
Wu, Wen Chieh ; Chen, Yung Tai ; Hwang, Chian Yaw ; Su, Chien Wei ; Li, Szu Yuan ; Chen, Tzeng Ji ; Liu, Chia Jen ; Kao, Wei Yu ; Chao, Yee ; Lin, Han Chieh ; Wu, Jaw Ching. / Second primary cancers in patients with hepatocellular carcinoma : A nationwide cohort study in Taiwan. In: Liver International. 2013 ; Vol. 33, No. 4. pp. 616-623.
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