Seasonal variations in serum sodium levels and other biochemical parameters among peritoneal dialysis patients

Szu Yuan Li, Jinn Yang Chen, Chiao L. Chuang, Tzen W. Chen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background. Although modest seasonal variations in blood biochemical composition have been reported in end-stage renal disease patients treated with haemodialysis, there have been no adequate explanations. The current study aimed to explore whether these phenomena are present in peritoneal dialysis patients and to discuss these variations. Methods. This was a retrospective study with an enrollment of 44 anuric PD patients. Serum biochemical parameters, peritoneal function, dialysis adequacy, peritoneal ultrafiltration volume and body weight were analysed in relation to climate variables for a study period of 2 years. Results. PD patients exhibited cyclic variations in blood biochemical concentrations. Monthly mean outdoor temperature was inversely correlated with serum concentrations of sodium (r = -0.712, P <0.001), potassium (r = -0.697, P <0.001), bicarbonate (r = -0.642, P <0.001), BUN (r = -0.654, P <0.001), albumin (r = -0.496, P = 0.012), peritoneal ultrafiltration volume (r = -0.723, P = 0.001) and body weight (r = -0.623, P <0.001). Serum chloride and creatinine concentrations were not correlated with temperature or other climate variables. Conclusions. PD patients showed seasonal variations in serum electrolyte concentration and peritoneal ultrafiltration volume. Monthly outdoor mean temperature was inversely correlated with serum electrolytes and ultrafiltration volume. A likely explanation is loss of these electrolytes through perspiration. Neglect of this annual cycle in PD patients may lead to biases in interpretation of clinical study and individual laboratory data.

Original languageEnglish
Pages (from-to)687-692
Number of pages6
JournalNephrology Dialysis Transplantation
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Peritoneal Dialysis
Sodium
Ultrafiltration
Serum
Electrolytes
Climate
Temperature
Body Weight
Blood Urea Nitrogen
Bicarbonates
Chronic Kidney Failure
Renal Dialysis
Chlorides
Albumins
Creatinine
Potassium
Retrospective Studies

Keywords

  • Electrolyte
  • End-stage renal disease
  • Peritoneal dialysis
  • Perspiration
  • Seasonal variation
  • Ultrafiltration

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Seasonal variations in serum sodium levels and other biochemical parameters among peritoneal dialysis patients. / Li, Szu Yuan; Chen, Jinn Yang; Chuang, Chiao L.; Chen, Tzen W.

In: Nephrology Dialysis Transplantation, Vol. 23, No. 2, 02.2008, p. 687-692.

Research output: Contribution to journalArticle

Li, Szu Yuan ; Chen, Jinn Yang ; Chuang, Chiao L. ; Chen, Tzen W. / Seasonal variations in serum sodium levels and other biochemical parameters among peritoneal dialysis patients. In: Nephrology Dialysis Transplantation. 2008 ; Vol. 23, No. 2. pp. 687-692.
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N2 - Background. Although modest seasonal variations in blood biochemical composition have been reported in end-stage renal disease patients treated with haemodialysis, there have been no adequate explanations. The current study aimed to explore whether these phenomena are present in peritoneal dialysis patients and to discuss these variations. Methods. This was a retrospective study with an enrollment of 44 anuric PD patients. Serum biochemical parameters, peritoneal function, dialysis adequacy, peritoneal ultrafiltration volume and body weight were analysed in relation to climate variables for a study period of 2 years. Results. PD patients exhibited cyclic variations in blood biochemical concentrations. Monthly mean outdoor temperature was inversely correlated with serum concentrations of sodium (r = -0.712, P <0.001), potassium (r = -0.697, P <0.001), bicarbonate (r = -0.642, P <0.001), BUN (r = -0.654, P <0.001), albumin (r = -0.496, P = 0.012), peritoneal ultrafiltration volume (r = -0.723, P = 0.001) and body weight (r = -0.623, P <0.001). Serum chloride and creatinine concentrations were not correlated with temperature or other climate variables. Conclusions. PD patients showed seasonal variations in serum electrolyte concentration and peritoneal ultrafiltration volume. Monthly outdoor mean temperature was inversely correlated with serum electrolytes and ultrafiltration volume. A likely explanation is loss of these electrolytes through perspiration. Neglect of this annual cycle in PD patients may lead to biases in interpretation of clinical study and individual laboratory data.

AB - Background. Although modest seasonal variations in blood biochemical composition have been reported in end-stage renal disease patients treated with haemodialysis, there have been no adequate explanations. The current study aimed to explore whether these phenomena are present in peritoneal dialysis patients and to discuss these variations. Methods. This was a retrospective study with an enrollment of 44 anuric PD patients. Serum biochemical parameters, peritoneal function, dialysis adequacy, peritoneal ultrafiltration volume and body weight were analysed in relation to climate variables for a study period of 2 years. Results. PD patients exhibited cyclic variations in blood biochemical concentrations. Monthly mean outdoor temperature was inversely correlated with serum concentrations of sodium (r = -0.712, P <0.001), potassium (r = -0.697, P <0.001), bicarbonate (r = -0.642, P <0.001), BUN (r = -0.654, P <0.001), albumin (r = -0.496, P = 0.012), peritoneal ultrafiltration volume (r = -0.723, P = 0.001) and body weight (r = -0.623, P <0.001). Serum chloride and creatinine concentrations were not correlated with temperature or other climate variables. Conclusions. PD patients showed seasonal variations in serum electrolyte concentration and peritoneal ultrafiltration volume. Monthly outdoor mean temperature was inversely correlated with serum electrolytes and ultrafiltration volume. A likely explanation is loss of these electrolytes through perspiration. Neglect of this annual cycle in PD patients may lead to biases in interpretation of clinical study and individual laboratory data.

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