Search for mutations near the alternatively spliced 8-amino-acid exon in the GABA(A) receptor γ2 subunit gene and lack of allelic association with alcoholism among four aboriginal groups and Han Chinese in Taiwan

Yun Pung P. Hsu, See Voon Seow, El Wei Loh, Yuan Chun Wang, Chiao Chicy Chen, Jeng Ming Yu, Andrew T.a. Cheng

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The alternatively spliced 8-amino-acid exon for the GABA(A) receptor γ2 subunit gene (GABRC2) has been postulated to mediate behavioral actions of alcohol. A rapid search for splice-junction mutations near the 8-amino-acid exon using restriction enzymes which normally recognize sequences near or in the exon gave negative results among 217 alcoholics in four aboriginal groups (Ami, Atayal, Bunun and Paiwan) and Han Chinese in Taiwan. The role of the GABRC2 gene in alcoholism was further assessed by a comparison of allelic frequencies revealed by a NciI RFLP between case and control groups. No significant association of alcohol dependence with GABRC2 alleles was observed. These results suggest that the GABRC2 gene probably does not play an essential role in predisposition to alcoholism in the sample population.

Original languageEnglish
Pages (from-to)284-286
Number of pages3
JournalMolecular Brain Research
Volume56
Issue number1-2
DOIs
Publication statusPublished - May 1 1998
Externally publishedYes

Fingerprint

GABA-A Receptors
Taiwan
Alcoholism
Exons
Amino Acids
Mutation
Genes
Alcoholics
Restriction Fragment Length Polymorphisms
Alleles
Alcohols
Control Groups
Enzymes
Population

Keywords

  • Alcoholism
  • Allelic association
  • Alternative splicing
  • GABA(A) receptor
  • Gamma 2 subunit
  • Mutation scan
  • Taiwanese aborigines

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Search for mutations near the alternatively spliced 8-amino-acid exon in the GABA(A) receptor γ2 subunit gene and lack of allelic association with alcoholism among four aboriginal groups and Han Chinese in Taiwan. / Hsu, Yun Pung P.; Seow, See Voon; Loh, El Wei; Wang, Yuan Chun; Chen, Chiao Chicy; Yu, Jeng Ming; Cheng, Andrew T.a.

In: Molecular Brain Research, Vol. 56, No. 1-2, 01.05.1998, p. 284-286.

Research output: Contribution to journalArticle

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AU - Loh, El Wei

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AU - Chen, Chiao Chicy

AU - Yu, Jeng Ming

AU - Cheng, Andrew T.a.

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