Screening of anti-HTLV antibody in sera of normal individuals and patients with malignancies in Taiwan

Po Min Chen, Chang Fang Chiu, Tzeon Jye Chiou, Cheng Hwai Tzeng, Sun Tien Lin, Lih Shinn Wang, Yeh Lee, Kwang Yu Chien, Sien Shih Chang, Sakan Maeda, William A. Blattner, Benjamin N. Chiang, Melvyn F. Greaves

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

In the present study an immunofluorescence using KH-2 cells as target cells, has been developed for the screening of 1200 serum samples from normal individuals and 450 of cases from patients with various malignancies. The positive anti-HTLV-I antibody rate in the former group is 0.083%(1/1200) and while in the latter it is found to be 1.8%(8/450) (including 3 adult T-cell leukemia/lymphoma cases of the 92 hematopoietic and 5 of 358 non-hematopoietic malignancies). The differences between the two groups are found to be significantly different (p value is <0.0001). In addition to the 3 adult T-cell leukemia/lymphoma cases, the 5 seropositive cancer patients are of 5 different diseases. We have searched for the adult T-cell leukemia virus antigen and the p19 core protein in lymphoid cells of seropositive persons and the only positive cases were from cells of two proven adult T-cell leukemia (ATL) patients. Our results suggest that Taiwan is not an endemic area of adult T-cell leukemia virus and that KH-2 cells may be used for the detection of anti-HTLV-I antibodies.

Original languageEnglish
Pages (from-to)369-373
Number of pages5
JournalLeukemia Research
Volume10
Issue number4
DOIs
Publication statusPublished - 1986
Externally publishedYes

Keywords

  • anti-HTLV-I antibody
  • ATLV
  • hematologic malignancy
  • HTLV-I
  • KH-2 cell line
  • p24 core protein

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Screening of anti-HTLV antibody in sera of normal individuals and patients with malignancies in Taiwan'. Together they form a unique fingerprint.

Cite this