Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro

Ray Ling Huang, Yu Ling Huang, Jun Chih Ou, Chien Chih Chen, Feng Lin Hsu, Chungming Chang

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76 Citations (Scopus)

Abstract

Using an HBV-producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multiflorus Willd., P. tenellus Roxb. and P. virgatus Forst. f.. It was found that niranthin (1), nirtetralin (3), hinokinin (5) and geraniin (13) at the non-cytotoxic concentration of 50 μM, suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively. Of these, niranthin (1) showed the best anti-HBsAg activity, while the most potent anti-HBeAg activity was observed with hinokinin (5).

Original languageEnglish
Pages (from-to)449-453
Number of pages5
JournalPhytotherapy Research
Volume17
Issue number5
DOIs
Publication statusPublished - May 2003

Keywords

  • Genus Phyllanthus
  • HBeAg
  • HBsAg
  • Hinokinin
  • Human hepatitis B virus
  • Niranthin

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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  • Cite this

    Huang, R. L., Huang, Y. L., Ou, J. C., Chen, C. C., Hsu, F. L., & Chang, C. (2003). Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro. Phytotherapy Research, 17(5), 449-453. https://doi.org/10.1002/ptr.1167