Schizophrenia and anteroventral thalamic nucleus

Selective decrease of parvalbumin-immunoreactive thalamocortical projection neurons

Peter Danos, Bruno Baumann, Hans Gert Bernstein, Michael Franz, Renate Stauch, Georg Northoff, Dieter Krell, Peter Falkai, Bernhard Bogerts

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

This study was designed to examine possible anatomical changes of thalamocortical circuits in schizophrenics. Previous immunocytochemical studies have shown that parvalbumin, a calcium-binding protein, occurs in thalamocortical projection neurons, but not in GABAergic interneurons in the anteroventral thalamic nucleus (AN). Using parvalbumin-immunocytochemistry we investigated the densities of thalamocortical projection neurons in the AN of schizophrenic cases (n = 12) and controls (n = 14). The densities of all neurons in the AN were estimated by Nissl-staining. The majority of thalamocortical projection neurons in AN were identified by parvalbumin- immunoreaction. Significantly reduced densities of thalamocortical projection neurons were estimated in the right (P = 0.003) and left AN (P = 0.018) in schizophrenic subjects. The densities of all neurons in right and left AN were also diminished in schizophrenics; however, these decreases did not reach statistical significance. The reductions of parvalbumin-positive thalamocortical projection neurons were not correlated with the length of disease, this finding supporting the neurodevelopmental etiology of structural abnormalities in schizophrenia.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalPsychiatry Research - Neuroimaging
Volume82
Issue number1
DOIs
Publication statusPublished - Apr 10 1998

Fingerprint

Anterior Thalamic Nuclei
Parvalbumins
Schizophrenia
Neurons
Calcium-Binding Proteins
Interneurons
Immunohistochemistry
Staining and Labeling

Keywords

  • Calcium- binding proteins
  • Limbic thalamus
  • Post-mortem studies
  • Thalamic projecting neurons

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

Schizophrenia and anteroventral thalamic nucleus : Selective decrease of parvalbumin-immunoreactive thalamocortical projection neurons. / Danos, Peter; Baumann, Bruno; Bernstein, Hans Gert; Franz, Michael; Stauch, Renate; Northoff, Georg; Krell, Dieter; Falkai, Peter; Bogerts, Bernhard.

In: Psychiatry Research - Neuroimaging, Vol. 82, No. 1, 10.04.1998, p. 1-10.

Research output: Contribution to journalArticle

Danos, Peter ; Baumann, Bruno ; Bernstein, Hans Gert ; Franz, Michael ; Stauch, Renate ; Northoff, Georg ; Krell, Dieter ; Falkai, Peter ; Bogerts, Bernhard. / Schizophrenia and anteroventral thalamic nucleus : Selective decrease of parvalbumin-immunoreactive thalamocortical projection neurons. In: Psychiatry Research - Neuroimaging. 1998 ; Vol. 82, No. 1. pp. 1-10.
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