Salvianolic acid B suppresses IFN-γ-induced JAK/STAT1 activation in endothelial cells

Shih Chung Chen, Yun Lian Lin, Bin Huang, Danny Ling Wang, Jing Jy Cheng

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Introduction: Dysfunction of the endothelium contributes to pathological conditions of the arterial wall including atherosclerosis as a result of immunological and/or inflammatory responses. Salvianolic acid B (Sal B), a pure and active compound extracted from the Chinese herb Salvia miltiorrhizae (SM) was characterized for its anti-inflammatory and anti-oxidant properties on vascular system. Methods and Results: Sal B pretreatment significantly inhibited the IFN-γ-induced phosphorylations of JAK2 (Tyr 1007/1008) and STAT1 (Tyr701 and Ser727). Consistently, IFN-γ-induced STAT1 downstream targets CXC chemokines' IP-10, Mig, and I-TAC were suppressed by Sal B pretreatment. Sal B inhibited promoter activities of IP-10 and the secretion of IP-10 protein. The monocyte adhesion to IFN-γ-treated ECs was observed to be reduced after Sal B pretreatment. ECs treated with Sal B alone also increased the expression of PIAS1 and SOCS1 which may also contribute to its inhibitory effect on JAK-STAT1 signaling pathways. Conclusions: The anti-inflammatory properties of Sal B on IFN-γ-induced JAK-STAT1 activation were demonstrated in the present study which provides a molecular basis for possible therapeutic usage on vascular disorders.

Original languageEnglish
Pages (from-to)560-564
Number of pages5
JournalThrombosis Research
Volume128
Issue number6
DOIs
Publication statusPublished - Dec 2011

Keywords

  • endothelial cells
  • IFN-γ
  • IP-10
  • JAK
  • salvianolic acid
  • STAT1

ASJC Scopus subject areas

  • Hematology

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