Salmonella enterica serotype Choleraesuis infection in a medical center in northern Taiwan

Shun Chiu, Cheng Hsun Chiu, Tzou Yien Lin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

This retrospective study was conducted in order to determine the clinical and microbiologic features of infection with Salmonella enterica serotype Choleraesuis. Between March 1999 and December 2002, 55 patients with 66 isolates were enrolled for analysis. The ratio of males to females was 2.2:1. Most patients were older than 60 years (56%) and had underlying diseases (78%), such as diabetes mellitus, malignancy, and peptic ulcer. Fever (85%) was the most common clinical manifestation, followed by abdominal pain/fullness (31%). The gastrointestinal manifestations, including nausea/vomiting or diarrhea, accounted for only 13% and 11% of patients, respectively. S. enterica serotype Choleraesuis was extremely invasive, with a high predilection to cause bacteremia (78% of the isolates were from blood). Various types of metastatic focal infections were found, including infected arterial aneurysm, osteomyelitis, septic arthritis, urinary tract infection and wound infection. The crude mortality rate was 18% (10 deaths in 55 cases). Nearly all isolates were susceptible to the third-generation cephalosporins. A higher resistance rate to commonly used antimicrobial agents was found with ampicillin (85%, 56/66), trimethoprim-sulfamethoxazole (81%, 40/49), chloramphenicol (96%, 47/49), and ciprofloxacin (49%, 30/61). In view of the emergence of fluoroquinolone resistance, the third-generation cephalosporins appear to be the best choice for treatment of invasive infections caused by this organism.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalJournal of Microbiology, Immunology and Infection
Volume37
Issue number2
Publication statusPublished - Apr 2004
Externally publishedYes

Keywords

  • Bacteremia
  • Infected aneurysm
  • Salmonella enterica
  • Taiwan

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)

Fingerprint Dive into the research topics of 'Salmonella enterica serotype Choleraesuis infection in a medical center in northern Taiwan'. Together they form a unique fingerprint.

  • Cite this