Salbutamol in the treatment of neonatal hyperkalemia

S. C. Mu, H. Y. Hung, C. H. Hsu, H. A. Kao, M. Y. Ho, F. Y. Huang

Research output: Contribution to journalArticle

Abstract

Neonatal hyperkalemia, a potentially life-threatening condition, is usually treated with intravenous insulin and glucose. However, this treatment can lead to hypoglycemia, which can be disastrous in newborns. In this study, we compared the effects of salbutamol and insulin plus glucose on the levels of potassium and glucose in hyperkalemic neonates. Two groups of infants, similar in age and pretreatment serum creatinine, glucose, and potassium, were studied. Group A (n = 23) received salbutamol inhalation (4 puffs, 100 μg per puff, and group B (n = 13) received insulin with glucose (0.5 g/kg/hr, with 1 unit insulin per 1-3 g glucose). Serum potassium and blood glucose were measured at 60, 120, 360 minutes after treatment. Both treatments reduced serum potassium, maximally at 60 minutes. Neonates in group A exhibited a significantly greater decrement in serum potassium, than those of group B at 60 minutes (-0.75 ± 0.14 VS -0.18 ± 0.12 mmol/L, respectively; p < 0.05). There was a maximal and significant decrement in blood glucose at 60 minutes in group B. The changes in blood glucose were -2.17 ± 4.25 and -59.38 ± 8.28 mg/dL, respectively (p < 1 x 10-7 These observations suggest that both salbutamol and insulin with glucose effectively lower plasma potassium concentrations in hyperkalemic neonates, although salbutamol seems to inducte a more significant effect. The hypoglycemic effect of insulin is marked compared to that of salbutamol in neonates. Thus, salbutamol is an effective alternative drug for the treatment of hyperkalemia in neonates.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalClinical Neonatology
Volume4
Issue number2
Publication statusPublished - Dec 1 1997
Externally publishedYes

Fingerprint

Hyperkalemia
Albuterol
Potassium
Glucose
Newborn Infant
Insulin
Blood Glucose
Serum
Therapeutics
Hypoglycemia
Hypoglycemic Agents
Inhalation
Creatinine
Pharmaceutical Preparations

Keywords

  • Hyperkalemia
  • Hypoglycemia
  • Infusion of insulin and glucose
  • Salbutamol

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Mu, S. C., Hung, H. Y., Hsu, C. H., Kao, H. A., Ho, M. Y., & Huang, F. Y. (1997). Salbutamol in the treatment of neonatal hyperkalemia. Clinical Neonatology, 4(2), 9-12.

Salbutamol in the treatment of neonatal hyperkalemia. / Mu, S. C.; Hung, H. Y.; Hsu, C. H.; Kao, H. A.; Ho, M. Y.; Huang, F. Y.

In: Clinical Neonatology, Vol. 4, No. 2, 01.12.1997, p. 9-12.

Research output: Contribution to journalArticle

Mu, SC, Hung, HY, Hsu, CH, Kao, HA, Ho, MY & Huang, FY 1997, 'Salbutamol in the treatment of neonatal hyperkalemia', Clinical Neonatology, vol. 4, no. 2, pp. 9-12.
Mu SC, Hung HY, Hsu CH, Kao HA, Ho MY, Huang FY. Salbutamol in the treatment of neonatal hyperkalemia. Clinical Neonatology. 1997 Dec 1;4(2):9-12.
Mu, S. C. ; Hung, H. Y. ; Hsu, C. H. ; Kao, H. A. ; Ho, M. Y. ; Huang, F. Y. / Salbutamol in the treatment of neonatal hyperkalemia. In: Clinical Neonatology. 1997 ; Vol. 4, No. 2. pp. 9-12.
@article{2d7a1258c4314e1e823081e2bf016786,
title = "Salbutamol in the treatment of neonatal hyperkalemia",
abstract = "Neonatal hyperkalemia, a potentially life-threatening condition, is usually treated with intravenous insulin and glucose. However, this treatment can lead to hypoglycemia, which can be disastrous in newborns. In this study, we compared the effects of salbutamol and insulin plus glucose on the levels of potassium and glucose in hyperkalemic neonates. Two groups of infants, similar in age and pretreatment serum creatinine, glucose, and potassium, were studied. Group A (n = 23) received salbutamol inhalation (4 puffs, 100 μg per puff, and group B (n = 13) received insulin with glucose (0.5 g/kg/hr, with 1 unit insulin per 1-3 g glucose). Serum potassium and blood glucose were measured at 60, 120, 360 minutes after treatment. Both treatments reduced serum potassium, maximally at 60 minutes. Neonates in group A exhibited a significantly greater decrement in serum potassium, than those of group B at 60 minutes (-0.75 ± 0.14 VS -0.18 ± 0.12 mmol/L, respectively; p < 0.05). There was a maximal and significant decrement in blood glucose at 60 minutes in group B. The changes in blood glucose were -2.17 ± 4.25 and -59.38 ± 8.28 mg/dL, respectively (p < 1 x 10-7 These observations suggest that both salbutamol and insulin with glucose effectively lower plasma potassium concentrations in hyperkalemic neonates, although salbutamol seems to inducte a more significant effect. The hypoglycemic effect of insulin is marked compared to that of salbutamol in neonates. Thus, salbutamol is an effective alternative drug for the treatment of hyperkalemia in neonates.",
keywords = "Hyperkalemia, Hypoglycemia, Infusion of insulin and glucose, Salbutamol",
author = "Mu, {S. C.} and Hung, {H. Y.} and Hsu, {C. H.} and Kao, {H. A.} and Ho, {M. Y.} and Huang, {F. Y.}",
year = "1997",
month = "12",
day = "1",
language = "English",
volume = "4",
pages = "9--12",
journal = "Clinical Neonatology",
issn = "1381-3390",
publisher = "Excerpta Medica Asia Ltd.",
number = "2",

}

TY - JOUR

T1 - Salbutamol in the treatment of neonatal hyperkalemia

AU - Mu, S. C.

AU - Hung, H. Y.

AU - Hsu, C. H.

AU - Kao, H. A.

AU - Ho, M. Y.

AU - Huang, F. Y.

PY - 1997/12/1

Y1 - 1997/12/1

N2 - Neonatal hyperkalemia, a potentially life-threatening condition, is usually treated with intravenous insulin and glucose. However, this treatment can lead to hypoglycemia, which can be disastrous in newborns. In this study, we compared the effects of salbutamol and insulin plus glucose on the levels of potassium and glucose in hyperkalemic neonates. Two groups of infants, similar in age and pretreatment serum creatinine, glucose, and potassium, were studied. Group A (n = 23) received salbutamol inhalation (4 puffs, 100 μg per puff, and group B (n = 13) received insulin with glucose (0.5 g/kg/hr, with 1 unit insulin per 1-3 g glucose). Serum potassium and blood glucose were measured at 60, 120, 360 minutes after treatment. Both treatments reduced serum potassium, maximally at 60 minutes. Neonates in group A exhibited a significantly greater decrement in serum potassium, than those of group B at 60 minutes (-0.75 ± 0.14 VS -0.18 ± 0.12 mmol/L, respectively; p < 0.05). There was a maximal and significant decrement in blood glucose at 60 minutes in group B. The changes in blood glucose were -2.17 ± 4.25 and -59.38 ± 8.28 mg/dL, respectively (p < 1 x 10-7 These observations suggest that both salbutamol and insulin with glucose effectively lower plasma potassium concentrations in hyperkalemic neonates, although salbutamol seems to inducte a more significant effect. The hypoglycemic effect of insulin is marked compared to that of salbutamol in neonates. Thus, salbutamol is an effective alternative drug for the treatment of hyperkalemia in neonates.

AB - Neonatal hyperkalemia, a potentially life-threatening condition, is usually treated with intravenous insulin and glucose. However, this treatment can lead to hypoglycemia, which can be disastrous in newborns. In this study, we compared the effects of salbutamol and insulin plus glucose on the levels of potassium and glucose in hyperkalemic neonates. Two groups of infants, similar in age and pretreatment serum creatinine, glucose, and potassium, were studied. Group A (n = 23) received salbutamol inhalation (4 puffs, 100 μg per puff, and group B (n = 13) received insulin with glucose (0.5 g/kg/hr, with 1 unit insulin per 1-3 g glucose). Serum potassium and blood glucose were measured at 60, 120, 360 minutes after treatment. Both treatments reduced serum potassium, maximally at 60 minutes. Neonates in group A exhibited a significantly greater decrement in serum potassium, than those of group B at 60 minutes (-0.75 ± 0.14 VS -0.18 ± 0.12 mmol/L, respectively; p < 0.05). There was a maximal and significant decrement in blood glucose at 60 minutes in group B. The changes in blood glucose were -2.17 ± 4.25 and -59.38 ± 8.28 mg/dL, respectively (p < 1 x 10-7 These observations suggest that both salbutamol and insulin with glucose effectively lower plasma potassium concentrations in hyperkalemic neonates, although salbutamol seems to inducte a more significant effect. The hypoglycemic effect of insulin is marked compared to that of salbutamol in neonates. Thus, salbutamol is an effective alternative drug for the treatment of hyperkalemia in neonates.

KW - Hyperkalemia

KW - Hypoglycemia

KW - Infusion of insulin and glucose

KW - Salbutamol

UR - http://www.scopus.com/inward/record.url?scp=0031427470&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031427470&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0031427470

VL - 4

SP - 9

EP - 12

JO - Clinical Neonatology

JF - Clinical Neonatology

SN - 1381-3390

IS - 2

ER -