S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors

Hsien Wei Yeh, Tzung Sheng Lin, Hsiao Wen Wang, Hou Wen Cheng, Der Zen Liu, Pi Hui Liang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.

Original languageEnglish
Pages (from-to)11518-11528
Number of pages11
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number47
DOIs
Publication statusPublished - 2015

Fingerprint

Bearings (structural)
influenza
Micelles
viruses
Orthomyxoviridae
Viruses
Liposomes
inhibitors
Sulfates
sulfates
Assays
micelles
congeners
Trisaccharides
H1N1 Subtype Influenza A Virus
Madin Darby Canine Kidney Cells
Hemagglutination
conjugation
entry
Phospholipids

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors. / Yeh, Hsien Wei; Lin, Tzung Sheng; Wang, Hsiao Wen; Cheng, Hou Wen; Liu, Der Zen; Liang, Pi Hui.

In: Organic and Biomolecular Chemistry, Vol. 13, No. 47, 2015, p. 11518-11528.

Research output: Contribution to journalArticle

Yeh, Hsien Wei ; Lin, Tzung Sheng ; Wang, Hsiao Wen ; Cheng, Hou Wen ; Liu, Der Zen ; Liang, Pi Hui. / S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors. In: Organic and Biomolecular Chemistry. 2015 ; Vol. 13, No. 47. pp. 11518-11528.
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