S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors

Hsien Wei Yeh, Tzung Sheng Lin, Hsiao Wen Wang, Hou Wen Cheng, Der Zen Liu, Pi Hui Liang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.

Original languageEnglish
Pages (from-to)11518-11528
Number of pages11
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number47
DOIs
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

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