S-ketamine and GABA-A-receptor interaction in humans: An exploratory study with I-123-iomazenil SPECT

Alexander Heinzel, Rainer Steinke, Thorsten Dirk Poeppel, Oliver Grosser, Bernhard Bogerts, Hans Otto, Georg Northoff

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: We aimed to probe for regional cerebral effects of S-ketamine on in vivo GABA-A-receptor binding in healthy human subjects. Methods: We investigated I-123-iomazenil SPECT before, during and after administration of S-ketamine in a blinded placebo-controlled study design (n = 12 in both groups). Analyses of SPECT were performed with voxel-based statistical parametric mapping (SPM), and statistical comparisons were made between the groups. We also assessed biochemical and behavioural changes during S-ketamine infusion. Results: S-ketamine induced positive and negative symptoms measured by the Brief Psychiatric Rating scale (BPRS). It increased the cortisol and prolactin levels. Image analysis revealed significantly decreased I-123-iomazenil binding in bilateral dorsomedial prefrontal cortex during S-ketamine administration when compared to placebo. Conclusion: Our study delivers preliminary evidence for an in vivo interaction of S-ketamine with GABA-A-receptors in human dorsomedial prefrontal cortex.

Original languageEnglish
Pages (from-to)549-554
Number of pages6
JournalHuman Psychopharmacology
Volume23
Issue number7
DOIs
Publication statusPublished - 2008

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Keywords

  • GABA-A
  • I-123-iomazenil
  • Medial prefrontal cortex
  • S-ketamine
  • SPECT

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Pharmacology (medical)

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