rs657075 (CSF2) is associated with the disease phenotype (BAS-G) of ankylosing spondylitis

Wei Chiao Chen, James Cheng Chung Wei, Hsing Fang Lu, Henry Sung Ching Wong, Peng Yeong Woon, Yu Wen Hsu, Jin Ding Huang, Wei Chiao Chang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Ankylosing spondylitis (AS) is a systemic autoimmune disease mainly affecting the lumbar spine and sacroiliac joints, and exhibits peripheral inflammatory arthropathy. More than 25 loci have been identified as associated with AS. Because both AS and rheumatoid arthritis (RA) are autoimmune diseases that may share some common genetic factors, we therefore examined if the newly identified RA genetic polymorphisms were associated with AS in a Taiwanese population. In this study, we enrolled 475 AS patients and 11,301 healthy subjects from a Taiwanese biobank as controls. Although none of single-nucleotide polymorphisms (SNPs) were associated with the susceptibility to AS, the AS disease index Bath AS Global (BAS-G) clinical phenotype was observed as significantly correlated to the AA genotype of rs657075 (CSF2). The significance remains after gender/age/disease duration adjustment and after group categorization by human leukocyte antigen-B 27 (HLA-B27) genotype. We further investigated the possible functions of rs657075 through bioinformatics approaches. Results revealed that polymorphism of rs657075 is able to influence the expression of acyl-CoA synthetase long-chain family member 6 (ACSL6). In conclusion, our study indicated that rs657075 (CSF2) is strongly associated with the AS disease index Bath AS Global (BAS-G) clinical phenotype.

Original languageEnglish
Article number83
JournalInternational Journal of Molecular Sciences
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 3 2017

Fingerprint

phenotype
Ankylosing Spondylitis
Baths
baths
polymorphism
Phenotype
Polymorphism
arthritis
Coenzyme A Ligases
leukocytes
spine
nucleotides
antigens
Antigens
Bioinformatics
loci
Nucleotides
HLA Antigens
Autoimmune Diseases
Rheumatoid Arthritis

Keywords

  • Ankylosing spondylitis
  • Bath AS Global (BAS-G)
  • CSF2
  • rs657075
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Computer Science Applications
  • Spectroscopy
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

rs657075 (CSF2) is associated with the disease phenotype (BAS-G) of ankylosing spondylitis. / Chen, Wei Chiao; Wei, James Cheng Chung; Lu, Hsing Fang; Wong, Henry Sung Ching; Woon, Peng Yeong; Hsu, Yu Wen; Huang, Jin Ding; Chang, Wei Chiao.

In: International Journal of Molecular Sciences, Vol. 18, No. 1, 83, 03.01.2017.

Research output: Contribution to journalArticle

Chen, Wei Chiao ; Wei, James Cheng Chung ; Lu, Hsing Fang ; Wong, Henry Sung Ching ; Woon, Peng Yeong ; Hsu, Yu Wen ; Huang, Jin Ding ; Chang, Wei Chiao. / rs657075 (CSF2) is associated with the disease phenotype (BAS-G) of ankylosing spondylitis. In: International Journal of Molecular Sciences. 2017 ; Vol. 18, No. 1.
@article{1567c94045be498eb43bb16964b0f2e6,
title = "rs657075 (CSF2) is associated with the disease phenotype (BAS-G) of ankylosing spondylitis",
abstract = "Ankylosing spondylitis (AS) is a systemic autoimmune disease mainly affecting the lumbar spine and sacroiliac joints, and exhibits peripheral inflammatory arthropathy. More than 25 loci have been identified as associated with AS. Because both AS and rheumatoid arthritis (RA) are autoimmune diseases that may share some common genetic factors, we therefore examined if the newly identified RA genetic polymorphisms were associated with AS in a Taiwanese population. In this study, we enrolled 475 AS patients and 11,301 healthy subjects from a Taiwanese biobank as controls. Although none of single-nucleotide polymorphisms (SNPs) were associated with the susceptibility to AS, the AS disease index Bath AS Global (BAS-G) clinical phenotype was observed as significantly correlated to the AA genotype of rs657075 (CSF2). The significance remains after gender/age/disease duration adjustment and after group categorization by human leukocyte antigen-B 27 (HLA-B27) genotype. We further investigated the possible functions of rs657075 through bioinformatics approaches. Results revealed that polymorphism of rs657075 is able to influence the expression of acyl-CoA synthetase long-chain family member 6 (ACSL6). In conclusion, our study indicated that rs657075 (CSF2) is strongly associated with the AS disease index Bath AS Global (BAS-G) clinical phenotype.",
keywords = "Ankylosing spondylitis, Bath AS Global (BAS-G), CSF2, rs657075, Single nucleotide polymorphism",
author = "Chen, {Wei Chiao} and Wei, {James Cheng Chung} and Lu, {Hsing Fang} and Wong, {Henry Sung Ching} and Woon, {Peng Yeong} and Hsu, {Yu Wen} and Huang, {Jin Ding} and Chang, {Wei Chiao}",
year = "2017",
month = "1",
day = "3",
doi = "10.3390/ijms18010083",
language = "English",
volume = "18",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "1",

}

TY - JOUR

T1 - rs657075 (CSF2) is associated with the disease phenotype (BAS-G) of ankylosing spondylitis

AU - Chen, Wei Chiao

AU - Wei, James Cheng Chung

AU - Lu, Hsing Fang

AU - Wong, Henry Sung Ching

AU - Woon, Peng Yeong

AU - Hsu, Yu Wen

AU - Huang, Jin Ding

AU - Chang, Wei Chiao

PY - 2017/1/3

Y1 - 2017/1/3

N2 - Ankylosing spondylitis (AS) is a systemic autoimmune disease mainly affecting the lumbar spine and sacroiliac joints, and exhibits peripheral inflammatory arthropathy. More than 25 loci have been identified as associated with AS. Because both AS and rheumatoid arthritis (RA) are autoimmune diseases that may share some common genetic factors, we therefore examined if the newly identified RA genetic polymorphisms were associated with AS in a Taiwanese population. In this study, we enrolled 475 AS patients and 11,301 healthy subjects from a Taiwanese biobank as controls. Although none of single-nucleotide polymorphisms (SNPs) were associated with the susceptibility to AS, the AS disease index Bath AS Global (BAS-G) clinical phenotype was observed as significantly correlated to the AA genotype of rs657075 (CSF2). The significance remains after gender/age/disease duration adjustment and after group categorization by human leukocyte antigen-B 27 (HLA-B27) genotype. We further investigated the possible functions of rs657075 through bioinformatics approaches. Results revealed that polymorphism of rs657075 is able to influence the expression of acyl-CoA synthetase long-chain family member 6 (ACSL6). In conclusion, our study indicated that rs657075 (CSF2) is strongly associated with the AS disease index Bath AS Global (BAS-G) clinical phenotype.

AB - Ankylosing spondylitis (AS) is a systemic autoimmune disease mainly affecting the lumbar spine and sacroiliac joints, and exhibits peripheral inflammatory arthropathy. More than 25 loci have been identified as associated with AS. Because both AS and rheumatoid arthritis (RA) are autoimmune diseases that may share some common genetic factors, we therefore examined if the newly identified RA genetic polymorphisms were associated with AS in a Taiwanese population. In this study, we enrolled 475 AS patients and 11,301 healthy subjects from a Taiwanese biobank as controls. Although none of single-nucleotide polymorphisms (SNPs) were associated with the susceptibility to AS, the AS disease index Bath AS Global (BAS-G) clinical phenotype was observed as significantly correlated to the AA genotype of rs657075 (CSF2). The significance remains after gender/age/disease duration adjustment and after group categorization by human leukocyte antigen-B 27 (HLA-B27) genotype. We further investigated the possible functions of rs657075 through bioinformatics approaches. Results revealed that polymorphism of rs657075 is able to influence the expression of acyl-CoA synthetase long-chain family member 6 (ACSL6). In conclusion, our study indicated that rs657075 (CSF2) is strongly associated with the AS disease index Bath AS Global (BAS-G) clinical phenotype.

KW - Ankylosing spondylitis

KW - Bath AS Global (BAS-G)

KW - CSF2

KW - rs657075

KW - Single nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=85008932613&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85008932613&partnerID=8YFLogxK

U2 - 10.3390/ijms18010083

DO - 10.3390/ijms18010083

M3 - Article

C2 - 28054948

AN - SCOPUS:85008932613

VL - 18

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 1

M1 - 83

ER -