rs10865331 associated with susceptibility and disease severity of ankylosing spondylitis in a Taiwanese population

Ya Feng Wen, James Cheng Chung Wei, Yu Wen Hsu, Hung Yi Chiou, Henry Sung Ching Wong, Ruey Hong Wong, Shiro Ikegawa, Wei Chiao Chang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Ankylosing spondylitis (AS) is a highly familial rheumatic disorder and is considered as a chronic inflammatory disease. Genetic factors are involved in the pathogenesis of AS. To identify genes which render people susceptible to AS in a Taiwanese population, we selected six single-nucleotide polymorphisms (SNPs) from previous genome-wide association studies (GWASs) which were associated with AS in European descendants and Han Chinese. To assess whether the six SNPs contributed to AS susceptibility and severity in Taiwanese population, 475 AS patients fulfilling the modified New York Criteria and 527 healthy subjects were recruited. We found that rs10865331 was significantly associated with AS susceptibility and with Bath AS Function Index (BASFI). The AA and AG genotypes of rs10865331 were also significantly associated with a higher erythrocyte sedimentation rate. Our findings provided evidence that rs10865331 is associated AS susceptibility and with disease activity (BASFI) in a Taiwanese population.

Original languageEnglish
Article numbere104525
JournalPLoS One
Volume9
Issue number9
DOIs
Publication statusPublished - 2014

Fingerprint

Ankylosing Spondylitis
Disease Susceptibility
Polymorphism
disease severity
Nucleotides
Genes
single nucleotide polymorphism
Sedimentation
Population
erythrocyte sedimentation rate
pathogenesis
Baths
Single Nucleotide Polymorphism
genotype
genes
Genome-Wide Association Study
Blood Sedimentation
Healthy Volunteers
Chronic Disease
Genotype

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

rs10865331 associated with susceptibility and disease severity of ankylosing spondylitis in a Taiwanese population. / Wen, Ya Feng; Wei, James Cheng Chung; Hsu, Yu Wen; Chiou, Hung Yi; Wong, Henry Sung Ching; Wong, Ruey Hong; Ikegawa, Shiro; Chang, Wei Chiao.

In: PLoS One, Vol. 9, No. 9, e104525, 2014.

Research output: Contribution to journalArticle

Wen, Ya Feng ; Wei, James Cheng Chung ; Hsu, Yu Wen ; Chiou, Hung Yi ; Wong, Henry Sung Ching ; Wong, Ruey Hong ; Ikegawa, Shiro ; Chang, Wei Chiao. / rs10865331 associated with susceptibility and disease severity of ankylosing spondylitis in a Taiwanese population. In: PLoS One. 2014 ; Vol. 9, No. 9.
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AU - Wong, Henry Sung Ching

AU - Wong, Ruey Hong

AU - Ikegawa, Shiro

AU - Chang, Wei Chiao

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