rs10865331 associated with susceptibility and disease severity of ankylosing spondylitis in a Taiwanese population

Ya Feng Wen, James Cheng Chung Wei, Yu Wen Hsu, Hung Yi Chiou, Henry Sung Ching Wong, Ruey Hong Wong, Shiro Ikegawa, Wei Chiao Chang

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Abstract

Ankylosing spondylitis (AS) is a highly familial rheumatic disorder and is considered as a chronic inflammatory disease. Genetic factors are involved in the pathogenesis of AS. To identify genes which render people susceptible to AS in a Taiwanese population, we selected six single-nucleotide polymorphisms (SNPs) from previous genome-wide association studies (GWASs) which were associated with AS in European descendants and Han Chinese. To assess whether the six SNPs contributed to AS susceptibility and severity in Taiwanese population, 475 AS patients fulfilling the modified New York Criteria and 527 healthy subjects were recruited. We found that rs10865331 was significantly associated with AS susceptibility and with Bath AS Function Index (BASFI). The AA and AG genotypes of rs10865331 were also significantly associated with a higher erythrocyte sedimentation rate. Our findings provided evidence that rs10865331 is associated AS susceptibility and with disease activity (BASFI) in a Taiwanese population.

Original languageEnglish
Article numbere104525
JournalPLoS One
Volume9
Issue number9
DOIs
Publication statusPublished - 2014

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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