rpoB genotypes of Mycobacterium tuberculosis Beijing family isolates from East Asian countries

Lishi Qian, Chiyoji Abe, Tao Ping Lin, Ming Chih Yu, Sang Nae Cho, Sumin Wang, James T. Douglas

Research output: Contribution to journalArticle

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Abstract

The 81-bp region of the rpoB gene in 66 Rif Mycobacterium tuberculosis isolates from China, Japan, Korea, and Taiwan was analyzed. Twelve single-nucleotide substitutions in the rpoB gene were detected. The most prevalent mutations were at Ser-531 (52%), Asp-516 (17%), and His-526 (11%). Mutations were not found in seven (11%) of the isolates. Higher mutation rates in 50 Beijing family isolates were found than in other isolates for mutations at Asp-516 (18 and 12.5%, respectively) and His-526 (12 and 6.3%, respectively). The different rates of mutation may reflect the choice of rifamycin analogs.

Original languageEnglish
Pages (from-to)1091-1094
Number of pages4
JournalJournal of Clinical Microbiology
Volume40
Issue number3
DOIs
Publication statusPublished - 2002
Externally publishedYes

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Mycobacterium tuberculosis
Genotype
Mutation Rate
Mutation
Korea
Taiwan
Genes
China
Japan
Nucleotides
Beijing

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

rpoB genotypes of Mycobacterium tuberculosis Beijing family isolates from East Asian countries. / Qian, Lishi; Abe, Chiyoji; Lin, Tao Ping; Yu, Ming Chih; Cho, Sang Nae; Wang, Sumin; Douglas, James T.

In: Journal of Clinical Microbiology, Vol. 40, No. 3, 2002, p. 1091-1094.

Research output: Contribution to journalArticle

Qian, Lishi ; Abe, Chiyoji ; Lin, Tao Ping ; Yu, Ming Chih ; Cho, Sang Nae ; Wang, Sumin ; Douglas, James T. / rpoB genotypes of Mycobacterium tuberculosis Beijing family isolates from East Asian countries. In: Journal of Clinical Microbiology. 2002 ; Vol. 40, No. 3. pp. 1091-1094.
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AU - Douglas, James T.

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