Rosmarinus officinalis extract suppresses propionibacterium acnes-induced inflammatory responses

Tsung-Hsien Tsai, Lu Te Chuang, Tsung Jung Lien, Yau Rong Liing, Wei Yu Chen, Po Jung Tsai

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Propionibacterium acnes is a key pathogen involved in the progression of acne inflammation. The development of a new agent possessing antimicrobial and anti-inflammatory activity against P. acnes is therefore of interest. In this study, we investigated the inhibitory effect of rosemary (Rosmarinus officinalis) extract on P. acnes-induced inflammation in vitro and in vivo. The results showed that ethanolic rosemary extract (ERE) significantly suppressed the secretion and mRNA expression of proinflammatory cytokines, including interleukin (IL)-8, IL-1β, and tumor necrosis factor-α in P. acnes-stimulated monocytic THP-1 cells. In an in vivo mouse model, concomitant intradermal injection of ERE attenuated the P. acnes-induced ear swelling and granulomatous inflammation. Since ERE suppressed the P. acnes-induced nuclear factor kappa-B (NF-κB) activation and mRNA expression of Toll-like receptor (TLR) 2, the suppressive effect of ERE might be due, at least partially, to diminished NF-κB activation and TLR2-mediated signaling pathways. Furthermore, three major constituents of ERE, carnosol, carnosic acid, and rosmarinic acid, exerted different immumodulatory activities in vitro. In brief, rosmarinic acid significantly suppressed IL-8 production, while the other two compounds inhibited IL-1β production. Further study is needed to explore the role of bioactive compounds of rosemary in mitigation of P. acnes-induced inflammation.

Original languageEnglish
Pages (from-to)324-333
Number of pages10
JournalJournal of Medicinal Food
Volume16
Issue number4
DOIs
Publication statusPublished - Apr 1 2013

Fingerprint

Rosmarinus
Propionibacterium acnes
Inflammation
NF-kappa B
Interleukin-8
Interleukin-1
Toll-Like Receptor 2
Intradermal Injections
Messenger RNA
Acne Vulgaris
Anti-Infective Agents
Ear
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
Cytokines

Keywords

  • anti-inflammation
  • NF-jB
  • Propionibacterium acnes
  • rosemary
  • TLR2

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Rosmarinus officinalis extract suppresses propionibacterium acnes-induced inflammatory responses. / Tsai, Tsung-Hsien; Chuang, Lu Te; Lien, Tsung Jung; Liing, Yau Rong; Chen, Wei Yu; Tsai, Po Jung.

In: Journal of Medicinal Food, Vol. 16, No. 4, 01.04.2013, p. 324-333.

Research output: Contribution to journalArticle

Tsai, Tsung-Hsien ; Chuang, Lu Te ; Lien, Tsung Jung ; Liing, Yau Rong ; Chen, Wei Yu ; Tsai, Po Jung. / Rosmarinus officinalis extract suppresses propionibacterium acnes-induced inflammatory responses. In: Journal of Medicinal Food. 2013 ; Vol. 16, No. 4. pp. 324-333.
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