Abstract
A marked decrease of klotho expression was observed in the kidney of streptozotocin-induced diabetic rats (STZ rats) showing diabetic nephropathy. It has been documented that klotho is the target gene of PPARγ. However, the effect of PPARγ agonist on klotho expression in kidney of STZ rats remains obscure. Thus, we used rosiglitazone (TZD) as PPARγ agonist to investigate the effect on renal dysfunction in STZ rats. Treatment of TZD reversed the lower levels of PPARγ, klotho, and FGFR1 expressions in kidneys of STZ rats without the correction of hyperglycemia. Also, renal functions and structural defeats were improved by TZD treatment. Taken together, oral administration of TZD may improve STZ-induced diabetic nephropathy due to restoration of the expression of klotho axis through an increase in PPARγ expression without changing blood glucose in rats.
| Original language | English |
|---|---|
| Pages (from-to) | 240-244 |
| Number of pages | 5 |
| Journal | Hormone and Metabolic Research |
| Volume | 46 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- diabetic nephropathy
- FGFR
- klotho
- PPARγ
- STZ rat
- TZD
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical
- Endocrinology, Diabetes and Metabolism
- Medicine(all)
Cite this
Rosiglitazone is effective to improve renal damage in type-1-like diabetic rats. / Huang, K. C.; Cherng, Yih-Giun; Chen, L. J.; Hsu, C. T.; Cheng, J. T.
In: Hormone and Metabolic Research, Vol. 46, No. 4, 2014, p. 240-244.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rosiglitazone is effective to improve renal damage in type-1-like diabetic rats
AU - Huang, K. C.
AU - Cherng, Yih-Giun
AU - Chen, L. J.
AU - Hsu, C. T.
AU - Cheng, J. T.
PY - 2014
Y1 - 2014
N2 - A marked decrease of klotho expression was observed in the kidney of streptozotocin-induced diabetic rats (STZ rats) showing diabetic nephropathy. It has been documented that klotho is the target gene of PPARγ. However, the effect of PPARγ agonist on klotho expression in kidney of STZ rats remains obscure. Thus, we used rosiglitazone (TZD) as PPARγ agonist to investigate the effect on renal dysfunction in STZ rats. Treatment of TZD reversed the lower levels of PPARγ, klotho, and FGFR1 expressions in kidneys of STZ rats without the correction of hyperglycemia. Also, renal functions and structural defeats were improved by TZD treatment. Taken together, oral administration of TZD may improve STZ-induced diabetic nephropathy due to restoration of the expression of klotho axis through an increase in PPARγ expression without changing blood glucose in rats.
AB - A marked decrease of klotho expression was observed in the kidney of streptozotocin-induced diabetic rats (STZ rats) showing diabetic nephropathy. It has been documented that klotho is the target gene of PPARγ. However, the effect of PPARγ agonist on klotho expression in kidney of STZ rats remains obscure. Thus, we used rosiglitazone (TZD) as PPARγ agonist to investigate the effect on renal dysfunction in STZ rats. Treatment of TZD reversed the lower levels of PPARγ, klotho, and FGFR1 expressions in kidneys of STZ rats without the correction of hyperglycemia. Also, renal functions and structural defeats were improved by TZD treatment. Taken together, oral administration of TZD may improve STZ-induced diabetic nephropathy due to restoration of the expression of klotho axis through an increase in PPARγ expression without changing blood glucose in rats.
KW - diabetic nephropathy
KW - FGFR
KW - klotho
KW - PPARγ
KW - STZ rat
KW - TZD
UR - http://www.scopus.com/inward/record.url?scp=84899480561&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899480561&partnerID=8YFLogxK
U2 - 10.1055/s-0033-1357161
DO - 10.1055/s-0033-1357161
M3 - Article
C2 - 24136780
AN - SCOPUS:84899480561
VL - 46
SP - 240
EP - 244
JO - Hormone and Metabolic Research
JF - Hormone and Metabolic Research
SN - 0018-5043
IS - 4
ER -