Roles of hepatic progenitor cells activation, ductular reaction proliferation and notch signaling in morbid obesity

Phui Ly Liew, Weu Wang, Yi Chih Lee, Ming Te Huang, Wei Jei Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)


Background/Aims: Hepatic progenitor cells (HPCs) activation, proliferative ductular reaction (DR), replicative arrest and Notch signaling have been demonstrated in a variety of human liver diseases. The relationships are poorly understood in morbid obesity. We investigated factors responsible for the HPCs/DR, replicative arrest and Notch signaling in non-NASH and NASH groups. Methodology: Cytokeratin 7 (and 19), p21, CD34, Ki67 and different Notch receptors and ligands immunohistochemical stained biopsies from morbid obese patients with non-NASH (n=10) and NASH (n=25) were studied. These results were correlated with clinicopathological variables. Results: NASH patients presented with abnormal liver function tests and had higher HbA1c percentage. Strong association between HPCs and DR was seen (r=0.785, p

Original languageEnglish
Pages (from-to)1921-1927
Number of pages7
Issue number118
Publication statusPublished - Sep 2012



  • Ductular reaction
  • Hepatic progenitor cells
  • Liver disease
  • Morbid obesity
  • Notch signaling

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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