Roles of EBUS-TBNA in non-small cell lung cancer

Fu Tsai Chung, Chih Hsi Kuo, Hao Cheng Chen, Po Hao Feng, Shu Min Lin, Chih Ten Yu, Chien Ying Liu, Chih Wei Wang, Han Pin Kuo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Endobronchial ultrasound-guided transbronchial aspiration (EBUSTBNA) has the potential to improve nodal diagnosis and staging in non-small cell lung cancer (NSCLC). This study was performed to explore the roles of EBUS-TBNA in NSCLC. Methods: From2007 to 2009, 164 NSCLC patientswere examined by EBUS-TBNA. The patients were divided into a diagnosis group (n = 64) and a staging group (n = 100). Results: For all patients, the diagnostic sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were 92.3%, 100%, 100%, 88.2%, and 95.1%, respectively. In the diagnosis group, the diagnostic sensitivity, specificity, PPV, NPV, and accuracy were 89.7%, 100%, 100%, 86.2%, and 94.4%, respectively. Thirty five patients (54.7%) positive for malignancy as determined by EBUS-TBNA avoided surgery. In the staging group, the diagnostic sensitivity, specificity,PPV,NPV, accuracy, and surgery avoidance rate were 93.8%, 100%, 100%, 89.7%, 96%, and 61%, respectively. Conclusions: EBUS-TBNA is a feasible and effective tool for NSCLC diagnosis and staging that also reduces surgery rates. Patients with NSCLC should initially undergo the less invasive EBUS-TBNA procedure for diagnosis and staging of NSCLC.However, negative findingsmust be confirmed by surgery.

Original languageEnglish
Pages (from-to)182-187
Number of pages6
JournalThoracic Cancer
Volume3
Issue number2
DOIs
Publication statusPublished - May 2012
Externally publishedYes

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Keywords

  • Diagnosis
  • EBUS-TBNA
  • NSCLC
  • Staging

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Chung, F. T., Kuo, C. H., Chen, H. C., Feng, P. H., Lin, S. M., Yu, C. T., Liu, C. Y., Wang, C. W., & Kuo, H. P. (2012). Roles of EBUS-TBNA in non-small cell lung cancer. Thoracic Cancer, 3(2), 182-187. https://doi.org/10.1111/j.1759-7714.2011.00093.x