Abstract

Adiponectin (APN) is an adipokine shown to have potent antiobesity, antiatherosclerotic, suppression of macrophage-to-foam cell transformation, and inhibition of proinflammatory cytokines. Studies have revealed that plasma concentration of APN is approximately three times higher in patients with end-stage kidney disease than in healthy people. However, low plasma levels of the hormone have been shown to elicit a protective effect against inflammation in animal models of ischemia/reperfusion-induced acute renal failure. This review summarizes the possible molecular signaling pathways involved in the effects of APN accumulation in the circulation on acute kidney injury in humans and in rodents.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalJournal of Experimental and Clinical Medicine(Taiwan)
Volume4
Issue number3
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Adiponectin
Acute Kidney Injury
Foam Cells
Adipokines
Chronic Kidney Failure
Reperfusion
Rodentia
Ischemia
Animal Models
Macrophages
Hormones
Cytokines
Inflammation

Keywords

  • Acute kidney injury
  • Adiponectin
  • Inflammation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Roles of Adiponectin in Acute Kidney Injury. / Chen, Hsi Hsien; Lin, Yen Chung; Chen, Tzen-Wen; Lin, Heng.

In: Journal of Experimental and Clinical Medicine(Taiwan), Vol. 4, No. 3, 06.2012, p. 145-148.

Research output: Contribution to journalArticle

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