Role of Vitamin D in Uremic Vascular Calcification

Yi Chou Hou, Wen Chih Liu, Cai Mei Zheng, Jing Quan Zheng, Tzung Hai Yen, Kuo Cheng Lu

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The risk of cardiovascular death is 10 times higher in patients with CKD (chronic kidney disease) than in those without CKD. Vascular calcification, common in patients with CKD, is a predictor of cardiovascular mortality. Vitamin D deficiency, another complication of CKD, is associated with vascular calcification in patients with CKD. GFR decline, proteinuria, tubulointerstitial injury, and the therapeutic dose of active form vitamin D aggravate vitamin D deficiency and reduce its pleiotropic effect on the cardiovascular system. Vitamin D supplement for CKD patients provides a protective role in vascular calcification on the endothelium by (1) renin-angiotensin-aldosterone system inactivation, (2) alleviating insulin resistance, (3) reduction of cholesterol and inhibition of foam cell and cholesterol efflux in macrophages, and (4) modulating vascular regeneration. For the arterial calcification, vitamin D supplement provides adjunctive role in regressing proteinuria, reverse renal osteodystrophy, and restoring calcification inhibitors. Recently, adventitial progenitor cell has been linked to be involved in the vascular calcification. Vitamin D may provide a role in modulating adventitial progenitor cells. In summary, vitamin D supplement may provide an ancillary role for ameliorating uremic vascular calcification.

Original languageEnglish
Article number2803579
JournalBioMed Research International
Volume2017
DOIs
Publication statusPublished - 2017

Fingerprint

Vascular Calcification
Chronic Renal Insufficiency
Vitamin D
Adventitia
Vitamin D Deficiency
Proteinuria
Stem Cells
Cholesterol
Chronic Kidney Disease-Mineral and Bone Disorder
Foam Cells
Cardiovascular system
Renin-Angiotensin System
Cardiovascular System
Macrophages
Angiotensins
Endothelium
Blood Vessels
Insulin Resistance
Aldosterone
Regeneration

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Role of Vitamin D in Uremic Vascular Calcification. / Hou, Yi Chou; Liu, Wen Chih; Zheng, Cai Mei; Zheng, Jing Quan; Yen, Tzung Hai; Lu, Kuo Cheng.

In: BioMed Research International, Vol. 2017, 2803579, 2017.

Research output: Contribution to journalReview article

Hou, Yi Chou ; Liu, Wen Chih ; Zheng, Cai Mei ; Zheng, Jing Quan ; Yen, Tzung Hai ; Lu, Kuo Cheng. / Role of Vitamin D in Uremic Vascular Calcification. In: BioMed Research International. 2017 ; Vol. 2017.
@article{328b209ba805476bb413dcdee1dc30e5,
title = "Role of Vitamin D in Uremic Vascular Calcification",
abstract = "The risk of cardiovascular death is 10 times higher in patients with CKD (chronic kidney disease) than in those without CKD. Vascular calcification, common in patients with CKD, is a predictor of cardiovascular mortality. Vitamin D deficiency, another complication of CKD, is associated with vascular calcification in patients with CKD. GFR decline, proteinuria, tubulointerstitial injury, and the therapeutic dose of active form vitamin D aggravate vitamin D deficiency and reduce its pleiotropic effect on the cardiovascular system. Vitamin D supplement for CKD patients provides a protective role in vascular calcification on the endothelium by (1) renin-angiotensin-aldosterone system inactivation, (2) alleviating insulin resistance, (3) reduction of cholesterol and inhibition of foam cell and cholesterol efflux in macrophages, and (4) modulating vascular regeneration. For the arterial calcification, vitamin D supplement provides adjunctive role in regressing proteinuria, reverse renal osteodystrophy, and restoring calcification inhibitors. Recently, adventitial progenitor cell has been linked to be involved in the vascular calcification. Vitamin D may provide a role in modulating adventitial progenitor cells. In summary, vitamin D supplement may provide an ancillary role for ameliorating uremic vascular calcification.",
author = "Hou, {Yi Chou} and Liu, {Wen Chih} and Zheng, {Cai Mei} and Zheng, {Jing Quan} and Yen, {Tzung Hai} and Lu, {Kuo Cheng}",
year = "2017",
doi = "10.1155/2017/2803579",
language = "English",
volume = "2017",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Role of Vitamin D in Uremic Vascular Calcification

AU - Hou, Yi Chou

AU - Liu, Wen Chih

AU - Zheng, Cai Mei

AU - Zheng, Jing Quan

AU - Yen, Tzung Hai

AU - Lu, Kuo Cheng

PY - 2017

Y1 - 2017

N2 - The risk of cardiovascular death is 10 times higher in patients with CKD (chronic kidney disease) than in those without CKD. Vascular calcification, common in patients with CKD, is a predictor of cardiovascular mortality. Vitamin D deficiency, another complication of CKD, is associated with vascular calcification in patients with CKD. GFR decline, proteinuria, tubulointerstitial injury, and the therapeutic dose of active form vitamin D aggravate vitamin D deficiency and reduce its pleiotropic effect on the cardiovascular system. Vitamin D supplement for CKD patients provides a protective role in vascular calcification on the endothelium by (1) renin-angiotensin-aldosterone system inactivation, (2) alleviating insulin resistance, (3) reduction of cholesterol and inhibition of foam cell and cholesterol efflux in macrophages, and (4) modulating vascular regeneration. For the arterial calcification, vitamin D supplement provides adjunctive role in regressing proteinuria, reverse renal osteodystrophy, and restoring calcification inhibitors. Recently, adventitial progenitor cell has been linked to be involved in the vascular calcification. Vitamin D may provide a role in modulating adventitial progenitor cells. In summary, vitamin D supplement may provide an ancillary role for ameliorating uremic vascular calcification.

AB - The risk of cardiovascular death is 10 times higher in patients with CKD (chronic kidney disease) than in those without CKD. Vascular calcification, common in patients with CKD, is a predictor of cardiovascular mortality. Vitamin D deficiency, another complication of CKD, is associated with vascular calcification in patients with CKD. GFR decline, proteinuria, tubulointerstitial injury, and the therapeutic dose of active form vitamin D aggravate vitamin D deficiency and reduce its pleiotropic effect on the cardiovascular system. Vitamin D supplement for CKD patients provides a protective role in vascular calcification on the endothelium by (1) renin-angiotensin-aldosterone system inactivation, (2) alleviating insulin resistance, (3) reduction of cholesterol and inhibition of foam cell and cholesterol efflux in macrophages, and (4) modulating vascular regeneration. For the arterial calcification, vitamin D supplement provides adjunctive role in regressing proteinuria, reverse renal osteodystrophy, and restoring calcification inhibitors. Recently, adventitial progenitor cell has been linked to be involved in the vascular calcification. Vitamin D may provide a role in modulating adventitial progenitor cells. In summary, vitamin D supplement may provide an ancillary role for ameliorating uremic vascular calcification.

UR - http://www.scopus.com/inward/record.url?scp=85014151003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014151003&partnerID=8YFLogxK

U2 - 10.1155/2017/2803579

DO - 10.1155/2017/2803579

M3 - Review article

C2 - 28286758

AN - SCOPUS:85014151003

VL - 2017

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 2803579

ER -