Role of T cells in type 2 diabetic nephropathy

Chia Chao Wu, Huey Kang Sytwu, Kuo Cheng Lu, Yuh Feng Lin

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Type 2 diabetic nephropathy (DN) is the most common cause of end-stage renal disease and is increasingly considered as an inflammatory disease characterized by leukocyte infiltration at every stage of renal involvement. Inflammation and activation of the immune system are closely involved in the pathogenesis of diabetes and its microvascular complications. Macrophage has been well recognized to play an important role in type 2 DN, leukocyte infiltration, and participated in process of DN, as was proposed recently. Th1, Th2, Th17, T reg, and cytotoxic T cells are involved in the development and progression of DN. The purpose of this review is to assemble current information concerning the role of T cells in the development and progression of type 2 DN. Specific emphasis is placed on the potential interaction and contribution of the T cells to renal damage. The therapeutic strategies involving T cells in the treatment of type 2 DN are also reviewed. Improving knowledge of the recognition of T cells as significant pathogenic mediators in DN reinforces the possibility of new potential therapeutic targets translated into future clinical treatments.

Original languageEnglish
Article number514738
JournalExperimental Diabetes Research
Volume2011
DOIs
Publication statusPublished - 2011

Fingerprint

Diabetic Nephropathies
T-Lymphocytes
Leukocytes
Kidney
Cells
Chronic Kidney Failure
Immune System
Macrophages
Inflammation
Therapeutics
Progression

ASJC Scopus subject areas

  • Medicine(all)
  • Endocrinology, Diabetes and Metabolism
  • Music

Cite this

Role of T cells in type 2 diabetic nephropathy. / Wu, Chia Chao; Sytwu, Huey Kang; Lu, Kuo Cheng; Lin, Yuh Feng.

In: Experimental Diabetes Research, Vol. 2011, 514738, 2011.

Research output: Contribution to journalArticle

Wu, Chia Chao ; Sytwu, Huey Kang ; Lu, Kuo Cheng ; Lin, Yuh Feng. / Role of T cells in type 2 diabetic nephropathy. In: Experimental Diabetes Research. 2011 ; Vol. 2011.
@article{c5e1ab54cbe04716933db473e81dd2ca,
title = "Role of T cells in type 2 diabetic nephropathy",
abstract = "Type 2 diabetic nephropathy (DN) is the most common cause of end-stage renal disease and is increasingly considered as an inflammatory disease characterized by leukocyte infiltration at every stage of renal involvement. Inflammation and activation of the immune system are closely involved in the pathogenesis of diabetes and its microvascular complications. Macrophage has been well recognized to play an important role in type 2 DN, leukocyte infiltration, and participated in process of DN, as was proposed recently. Th1, Th2, Th17, T reg, and cytotoxic T cells are involved in the development and progression of DN. The purpose of this review is to assemble current information concerning the role of T cells in the development and progression of type 2 DN. Specific emphasis is placed on the potential interaction and contribution of the T cells to renal damage. The therapeutic strategies involving T cells in the treatment of type 2 DN are also reviewed. Improving knowledge of the recognition of T cells as significant pathogenic mediators in DN reinforces the possibility of new potential therapeutic targets translated into future clinical treatments.",
author = "Wu, {Chia Chao} and Sytwu, {Huey Kang} and Lu, {Kuo Cheng} and Lin, {Yuh Feng}",
year = "2011",
doi = "10.1155/2011/514738",
language = "English",
volume = "2011",
journal = "Experimental Diabesity Research",
issn = "1543-8600",
publisher = "Taylor and Francis Ltd.",

}

TY - JOUR

T1 - Role of T cells in type 2 diabetic nephropathy

AU - Wu, Chia Chao

AU - Sytwu, Huey Kang

AU - Lu, Kuo Cheng

AU - Lin, Yuh Feng

PY - 2011

Y1 - 2011

N2 - Type 2 diabetic nephropathy (DN) is the most common cause of end-stage renal disease and is increasingly considered as an inflammatory disease characterized by leukocyte infiltration at every stage of renal involvement. Inflammation and activation of the immune system are closely involved in the pathogenesis of diabetes and its microvascular complications. Macrophage has been well recognized to play an important role in type 2 DN, leukocyte infiltration, and participated in process of DN, as was proposed recently. Th1, Th2, Th17, T reg, and cytotoxic T cells are involved in the development and progression of DN. The purpose of this review is to assemble current information concerning the role of T cells in the development and progression of type 2 DN. Specific emphasis is placed on the potential interaction and contribution of the T cells to renal damage. The therapeutic strategies involving T cells in the treatment of type 2 DN are also reviewed. Improving knowledge of the recognition of T cells as significant pathogenic mediators in DN reinforces the possibility of new potential therapeutic targets translated into future clinical treatments.

AB - Type 2 diabetic nephropathy (DN) is the most common cause of end-stage renal disease and is increasingly considered as an inflammatory disease characterized by leukocyte infiltration at every stage of renal involvement. Inflammation and activation of the immune system are closely involved in the pathogenesis of diabetes and its microvascular complications. Macrophage has been well recognized to play an important role in type 2 DN, leukocyte infiltration, and participated in process of DN, as was proposed recently. Th1, Th2, Th17, T reg, and cytotoxic T cells are involved in the development and progression of DN. The purpose of this review is to assemble current information concerning the role of T cells in the development and progression of type 2 DN. Specific emphasis is placed on the potential interaction and contribution of the T cells to renal damage. The therapeutic strategies involving T cells in the treatment of type 2 DN are also reviewed. Improving knowledge of the recognition of T cells as significant pathogenic mediators in DN reinforces the possibility of new potential therapeutic targets translated into future clinical treatments.

UR - http://www.scopus.com/inward/record.url?scp=84555188233&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84555188233&partnerID=8YFLogxK

U2 - 10.1155/2011/514738

DO - 10.1155/2011/514738

M3 - Article

VL - 2011

JO - Experimental Diabesity Research

JF - Experimental Diabesity Research

SN - 1543-8600

M1 - 514738

ER -