Role of sentinel lymphadenectomy combined with intraoperative ultrasound in the assessment of locally advanced breast cancer after neoadjuvant chemotherapy

Jyh Cherng Yu, Giu Cheng Hsu, Chung Bo Hsieh, Cheng Ping Yu, Tsu Yi Chao

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Sentinel node (SN) biopsy for patients with locally advanced breast cancer after neoadjuvant chemotherapy results in a lower detection rate and higher false-negative rate. The aims of the study were to explore the role of SN biopsy in these patients in Taiwan and to assess the role of intraoperative ultrasound examination of the non-SN level. Methods: We used a blue dye to identify the SNs in 127 patients with T3 locally advanced breast cancer initially treated with neoadjuvant chemotherapy. After SN biopsy, we used intraoperative ultrasound to explore the non-SN region for additional lymph nodes, followed by at least level II axillary dissection. All the SNs were evaluated histologically and immunohistochemically with anticytokeratin antibodies. All the non-SNs were examined by routine histology. Results: SNs were identified in 116 (91.3%) of 127 procedures. SN metastases were found in 64 cases (55.2%). Subsequent axillary dissection revealed tumor involvement of non-SNs in 40 (62.5%) of 64 cases. SN biopsy results had a sensitivity of 92.8%, a specificity of 100%, and a false-negative rate of 9.6%. Furthermore, intraoperative ultrasound detected suspicious malignant nodes in the non-SN level in 39 out of 40 cases, and detected 5 cases with non-SN metastases that had false-negative SN mapping. This technique decreased the false-negative rate of SN mapping from 9.6% to only 1.39% for these cases. Conclusions: SN biopsy results combined with intraoperative ultrasonography can accurately assess the non-SN status and help breast surgeons to decide whether subsequent axillary dissection is warranted after SN biopsy has been performed.

Original languageEnglish
Pages (from-to)174-180
Number of pages7
JournalAnnals of Surgical Oncology
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2007
Externally publishedYes

Fingerprint

Lymph Node Excision
Breast Neoplasms
Drug Therapy
Biopsy
Dissection
Neoplasm Metastasis
cyhalothrin
Taiwan
Ultrasonography
Histology
Breast
Coloring Agents
Lymph Nodes
Antibodies

Keywords

  • Intraoperative ultrasound
  • Non-SN metastasis
  • Sentinel node
  • SN biopsy

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Role of sentinel lymphadenectomy combined with intraoperative ultrasound in the assessment of locally advanced breast cancer after neoadjuvant chemotherapy. / Yu, Jyh Cherng; Hsu, Giu Cheng; Hsieh, Chung Bo; Yu, Cheng Ping; Chao, Tsu Yi.

In: Annals of Surgical Oncology, Vol. 14, No. 1, 01.2007, p. 174-180.

Research output: Contribution to journalArticle

@article{8dfaa4fd7a4842bdb6f55d89a47fd6b9,
title = "Role of sentinel lymphadenectomy combined with intraoperative ultrasound in the assessment of locally advanced breast cancer after neoadjuvant chemotherapy",
abstract = "Background: Sentinel node (SN) biopsy for patients with locally advanced breast cancer after neoadjuvant chemotherapy results in a lower detection rate and higher false-negative rate. The aims of the study were to explore the role of SN biopsy in these patients in Taiwan and to assess the role of intraoperative ultrasound examination of the non-SN level. Methods: We used a blue dye to identify the SNs in 127 patients with T3 locally advanced breast cancer initially treated with neoadjuvant chemotherapy. After SN biopsy, we used intraoperative ultrasound to explore the non-SN region for additional lymph nodes, followed by at least level II axillary dissection. All the SNs were evaluated histologically and immunohistochemically with anticytokeratin antibodies. All the non-SNs were examined by routine histology. Results: SNs were identified in 116 (91.3{\%}) of 127 procedures. SN metastases were found in 64 cases (55.2{\%}). Subsequent axillary dissection revealed tumor involvement of non-SNs in 40 (62.5{\%}) of 64 cases. SN biopsy results had a sensitivity of 92.8{\%}, a specificity of 100{\%}, and a false-negative rate of 9.6{\%}. Furthermore, intraoperative ultrasound detected suspicious malignant nodes in the non-SN level in 39 out of 40 cases, and detected 5 cases with non-SN metastases that had false-negative SN mapping. This technique decreased the false-negative rate of SN mapping from 9.6{\%} to only 1.39{\%} for these cases. Conclusions: SN biopsy results combined with intraoperative ultrasonography can accurately assess the non-SN status and help breast surgeons to decide whether subsequent axillary dissection is warranted after SN biopsy has been performed.",
keywords = "Intraoperative ultrasound, Non-SN metastasis, Sentinel node, SN biopsy",
author = "Yu, {Jyh Cherng} and Hsu, {Giu Cheng} and Hsieh, {Chung Bo} and Yu, {Cheng Ping} and Chao, {Tsu Yi}",
year = "2007",
month = "1",
doi = "10.1245/s10434-006-9132-7",
language = "English",
volume = "14",
pages = "174--180",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Role of sentinel lymphadenectomy combined with intraoperative ultrasound in the assessment of locally advanced breast cancer after neoadjuvant chemotherapy

AU - Yu, Jyh Cherng

AU - Hsu, Giu Cheng

AU - Hsieh, Chung Bo

AU - Yu, Cheng Ping

AU - Chao, Tsu Yi

PY - 2007/1

Y1 - 2007/1

N2 - Background: Sentinel node (SN) biopsy for patients with locally advanced breast cancer after neoadjuvant chemotherapy results in a lower detection rate and higher false-negative rate. The aims of the study were to explore the role of SN biopsy in these patients in Taiwan and to assess the role of intraoperative ultrasound examination of the non-SN level. Methods: We used a blue dye to identify the SNs in 127 patients with T3 locally advanced breast cancer initially treated with neoadjuvant chemotherapy. After SN biopsy, we used intraoperative ultrasound to explore the non-SN region for additional lymph nodes, followed by at least level II axillary dissection. All the SNs were evaluated histologically and immunohistochemically with anticytokeratin antibodies. All the non-SNs were examined by routine histology. Results: SNs were identified in 116 (91.3%) of 127 procedures. SN metastases were found in 64 cases (55.2%). Subsequent axillary dissection revealed tumor involvement of non-SNs in 40 (62.5%) of 64 cases. SN biopsy results had a sensitivity of 92.8%, a specificity of 100%, and a false-negative rate of 9.6%. Furthermore, intraoperative ultrasound detected suspicious malignant nodes in the non-SN level in 39 out of 40 cases, and detected 5 cases with non-SN metastases that had false-negative SN mapping. This technique decreased the false-negative rate of SN mapping from 9.6% to only 1.39% for these cases. Conclusions: SN biopsy results combined with intraoperative ultrasonography can accurately assess the non-SN status and help breast surgeons to decide whether subsequent axillary dissection is warranted after SN biopsy has been performed.

AB - Background: Sentinel node (SN) biopsy for patients with locally advanced breast cancer after neoadjuvant chemotherapy results in a lower detection rate and higher false-negative rate. The aims of the study were to explore the role of SN biopsy in these patients in Taiwan and to assess the role of intraoperative ultrasound examination of the non-SN level. Methods: We used a blue dye to identify the SNs in 127 patients with T3 locally advanced breast cancer initially treated with neoadjuvant chemotherapy. After SN biopsy, we used intraoperative ultrasound to explore the non-SN region for additional lymph nodes, followed by at least level II axillary dissection. All the SNs were evaluated histologically and immunohistochemically with anticytokeratin antibodies. All the non-SNs were examined by routine histology. Results: SNs were identified in 116 (91.3%) of 127 procedures. SN metastases were found in 64 cases (55.2%). Subsequent axillary dissection revealed tumor involvement of non-SNs in 40 (62.5%) of 64 cases. SN biopsy results had a sensitivity of 92.8%, a specificity of 100%, and a false-negative rate of 9.6%. Furthermore, intraoperative ultrasound detected suspicious malignant nodes in the non-SN level in 39 out of 40 cases, and detected 5 cases with non-SN metastases that had false-negative SN mapping. This technique decreased the false-negative rate of SN mapping from 9.6% to only 1.39% for these cases. Conclusions: SN biopsy results combined with intraoperative ultrasonography can accurately assess the non-SN status and help breast surgeons to decide whether subsequent axillary dissection is warranted after SN biopsy has been performed.

KW - Intraoperative ultrasound

KW - Non-SN metastasis

KW - Sentinel node

KW - SN biopsy

UR - http://www.scopus.com/inward/record.url?scp=33845638411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845638411&partnerID=8YFLogxK

U2 - 10.1245/s10434-006-9132-7

DO - 10.1245/s10434-006-9132-7

M3 - Article

C2 - 17066228

AN - SCOPUS:33845638411

VL - 14

SP - 174

EP - 180

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 1

ER -