Role of placental fibrinogen-like protein 1 in gestational diabetes

Lin Kang, Hung Yuan Li, Horng Yih Ou, Pensee Wu, Shu Huei Wang, Chih Jen Chang, Shin Yu Lin, Chao Liang Wu, Hung Tsung Wu

Research output: Contribution to journalArticle

Abstract

In view of the increasing prevalence of gestational diabetes mellitus (GDM) and the increased risks of delivering a macrosomic infant, developing preeclampsia, and suffering a perinatal death due to GDM, GDM has emerged as a growing public health problem. Although the placenta was suggested to play a crucial role in the pathology of GDM, the mechanisms that induce the development of GDM are still obscure. Fibrinogen-like protein (FGL)-1 is a hepatokine that plays an important role in hepatogenesis, as well as in nonalcoholic fatty liver disease and diabetes. Although FGL-1 is also expressed by the placenta, the pathophysiological role of FGL-1 in GDM is still unknown. In this study, FGL-1 levels were evaluated in 45 subjects with (n = 16) or without (n = 29) GDM. We found that FGL-1 was mainly expressed by placental trophoblasts, and FGL-1 expression was significantly higher in subjects with GDM. FGL-1 increased trophoblast proliferation through an extracellular signal-regulated kinase 1/2-dependent pathway. In addition, plasma concentrations of FGL-1 were higher in subjects with GDM, and the increased circulating FGL-1 might contribute to systemic insulin resistance. FGL-1 disrupted the gluconeogenic action of insulin in HepG2 cells, and decreased insulin-induced glucose uptake by L6 myotubes. Taken together, placental FGL-1 possibly plays a role in the impairment of insulin function in the development of GDM, and it might be a novel biomarker for diagnosing GDM.

Original languageEnglish
JournalTranslational Research
DOIs
Publication statusAccepted/In press - Jan 1 2020

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical
  • Physiology (medical)

Cite this

Kang, L., Li, H. Y., Ou, H. Y., Wu, P., Wang, S. H., Chang, C. J., Lin, S. Y., Wu, C. L., & Wu, H. T. (Accepted/In press). Role of placental fibrinogen-like protein 1 in gestational diabetes. Translational Research. https://doi.org/10.1016/j.trsl.2020.01.001