Role of oxygen-derived free radicals in the mechanism of cysteamine-induced duodenal ulcer in rats

S. H. Chen, S. Pan, K. Okita, T. Takemoto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In this study, the possible role of oxygen-derived free radicals in cysteamine-induced duodenal ulcers in rats was investigated. Separate groups of rats were treated with 350 mg/kg cysteamine subcutaneously. Superoxide dismutase (SOD) activity and thiobarbituric acid (TBA) reactants in the duodenal mucosa were analyzed one, three, six, 12 and 24 hours after treatment, respectively. Cu,Zn-SOD activity significantly decreased from 41.79 ± 3.53 NU/mg protein to 29.56 ± 3.62, 27.23 ± 3.02 and 24.64 ± 3.07 NU/mg protein at three, six and 12 hours, respectively. TBA reactants, indicators of tissue injury by oxygen-derived free radicals, significantly increased from 0.18 ± 0.10 nmol/mg protein to 1.31 ± 0.12 and 1.57 ± 0.09 nmol/mg protein at six and 12 hours after cysteamine treatment, respectively. We conclude that an increase of oxygen-derived free radicals and a decrease of Cu,Zn-SOD activity in the duodenal mucosa may be involved in the pathogenesis of cysteamine-induced duodenal ulcers in rats.

Original languageEnglish
Pages (from-to)11-14
Number of pages4
JournalJournal of the Formosan Medical Association
Volume93
Issue number1
Publication statusPublished - 1994

Fingerprint

Cysteamine
Duodenal Ulcer
Free Radicals
Oxygen
Mucous Membrane
Proteins
Superoxide Dismutase
Wounds and Injuries
Superoxide Dismutase-1
thiobarbituric acid

Keywords

  • cysteamine
  • duodenal ulcer
  • lipid peroxidation
  • oxygen-derived free radicals
  • superoxide dismutase

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Role of oxygen-derived free radicals in the mechanism of cysteamine-induced duodenal ulcer in rats. / Chen, S. H.; Pan, S.; Okita, K.; Takemoto, T.

In: Journal of the Formosan Medical Association, Vol. 93, No. 1, 1994, p. 11-14.

Research output: Contribution to journalArticle

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