Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer

C. W. Lin, S. W. Tseng, S. F. Yang, C. P. Ko, Chien-Huang Lin, L. H. Wei, M. H. Chien, Y. S. Hsieh

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objectives: Recent evidence demonstrated that lipocalin (LCN)2 is induced in many types of human cancer, while the detection of its complex with matrix metalloproteinase (MMP)-9 is correlated with the cancer disease status. We attempted to evaluate plasma expressions of LCN2, MMP-9, and their complex (LCN2/MMP-9) during the diagnostic work-up of patients with oral squamous cell carcinoma (OSCC) and investigated their correlations with disease progression. Methods: In total, 195 patients with OSCC and 81 healthy controls were recruited. Expression levels of LCN2, MMP-9, and LCN2/MMP-9 were determined with immunoenzymatic assays. Results: Patients with OSCC exhibited significantly higher levels of LCN2, MMP-9, and LCN2/MMP-9 compared with healthy controls (LCN2: P

Original languageEnglish
Pages (from-to)734-740
Number of pages7
JournalOral Diseases
Volume18
Issue number8
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Lipocalin 2
  • Matrix metalloproteinase-9
  • Oral squamous cell carcinoma

ASJC Scopus subject areas

  • Dentistry(all)
  • Otorhinolaryngology

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