Role of inward rectifier potassium current on drug therapy of atrial fibrillation

Cheng Jeng Tai; Wen Hung Chao; Shih ann Chen; John K J Li; Po Min Chen; Jui chien Hsieh

Role of inward rectifier potassium current on drug therapy of atrial fibrillation

Cheng Jeng Tai, Wen Hung Chao, Shih ann Chen, John K J Li, Po Min Chen, Jui chien Hsieh

Research output: Contribution to journal › Article › peer-review

Abstract

An S1-S2 stimulus protocol was used to test membrane threshold and subthreshold inactivation in relationship to prematurity and the conductance of IK1 (gk1). Results indicated that (1) required charge threshold for S2 was exponentially related to gk1 regardless of coupling interval both of normal and of fibrillation-induced cells; and (2) peak of sodium currents initiated by S2 was parabolically related to baseline gk1 with 70% maximum sodium currents occurring at 33% reduced gk1 in the fibrillation induced model cell only.

Original language	English
Journal	Annals of Biomedical Engineering
Volume	28
Issue number	SUPPL. 1
Publication status	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Biomedical Engineering

Cite this

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title = "Role of inward rectifier potassium current on drug therapy of atrial fibrillation",

abstract = "An S1-S2 stimulus protocol was used to test membrane threshold and subthreshold inactivation in relationship to prematurity and the conductance of IK1 (gk1). Results indicated that (1) required charge threshold for S2 was exponentially related to gk1 regardless of coupling interval both of normal and of fibrillation-induced cells; and (2) peak of sodium currents initiated by S2 was parabolically related to baseline gk1 with 70% maximum sodium currents occurring at 33% reduced gk1 in the fibrillation induced model cell only.",

author = "Tai, {Cheng Jeng} and Chao, {Wen Hung} and Chen, {Shih ann} and Li, {John K J} and Chen, {Po Min} and Hsieh, {Jui chien}",

year = "2000",

language = "English",

volume = "28",

journal = "Annals of Biomedical Engineering",

issn = "0090-6964",

publisher = "Springer Netherlands",

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T1 - Role of inward rectifier potassium current on drug therapy of atrial fibrillation

AU - Tai, Cheng Jeng

AU - Chao, Wen Hung

AU - Chen, Shih ann

AU - Li, John K J

AU - Chen, Po Min

AU - Hsieh, Jui chien

PY - 2000

Y1 - 2000

N2 - An S1-S2 stimulus protocol was used to test membrane threshold and subthreshold inactivation in relationship to prematurity and the conductance of IK1 (gk1). Results indicated that (1) required charge threshold for S2 was exponentially related to gk1 regardless of coupling interval both of normal and of fibrillation-induced cells; and (2) peak of sodium currents initiated by S2 was parabolically related to baseline gk1 with 70% maximum sodium currents occurring at 33% reduced gk1 in the fibrillation induced model cell only.

AB - An S1-S2 stimulus protocol was used to test membrane threshold and subthreshold inactivation in relationship to prematurity and the conductance of IK1 (gk1). Results indicated that (1) required charge threshold for S2 was exponentially related to gk1 regardless of coupling interval both of normal and of fibrillation-induced cells; and (2) peak of sodium currents initiated by S2 was parabolically related to baseline gk1 with 70% maximum sodium currents occurring at 33% reduced gk1 in the fibrillation induced model cell only.

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M3 - Article

AN - SCOPUS:0034507109

SN - 0090-6964

VL - 28

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

IS - SUPPL. 1

ER -

Role of inward rectifier potassium current on drug therapy of atrial fibrillation

Abstract

ASJC Scopus subject areas

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