Role of interleukin-17F in chronic inflammatory and allergic lung disease

N. Hizawa, M. Kawaguchi, S. K. Huang, M. Nishimura

Research output: Contribution to journalReview article

85 Citations (Scopus)

Abstract

IL-17 family members belong to a distinct category of cytokines that coordinate local tissue inflammation by inducing the release of pro-inflammatory and neutrophil-mobilizing cytokines. The importance of the IL-17 family in inflammatory and autoimmune disease is becoming increasingly apparent. IL-17F is a recently discovered member of the IL-17 family that has a number of biological activities through induction of various cytokines, chemokines, and mediators. IL-17A, the founding member of the IL-17 family, and IL-17F are produced by several inflammatory cells, including activated T cells, in response to infectious and antigenic stimuli. Overexpression of IL-17A or IL-17F in the lungs results in induction of CXC chemokines and neutrophil recruitment. In a case-control study of 1125 unrelated Japanese subjects, a His161 to Arg161 (H161R) substitution in the third exon of the IL17F gene was shown to be associated with asthma and chronic obstructive pulmonary disease (COPD). Functionally, this variant failed to induce cytokines and chemokines, and interestingly, was able to antagonize the activity of wild-type IL-17F. These results provide an experimental basis for the observed genetic association with chronic inflammatory lung diseases, and also suggest the potential therapeutic utility of this antagonistic variant of IL-17F. Given that asthma and COPD are complex diseases involving a number of genetic and environmental factors, the genetic impact of IL-17F H161R with regard to the development of chronic airway inflammation likely varies among individuals with different genetic backgrounds and environmental exposures.

Original languageEnglish
Pages (from-to)1109-1114
Number of pages6
JournalClinical and Experimental Allergy
Volume36
Issue number9
DOIs
Publication statusPublished - Sep 1 2006
Externally publishedYes

Fingerprint

Interleukin-17
Lung Diseases
Cytokines
Chemokines
Chronic Obstructive Pulmonary Disease
Asthma
Inflammation
CXC Chemokines
Neutrophil Infiltration
Environmental Exposure
Autoimmune Diseases
Case-Control Studies
Exons
Neutrophils

Keywords

  • Asthma
  • Atopy
  • COPD
  • IL-17F

ASJC Scopus subject areas

  • Immunology

Cite this

Role of interleukin-17F in chronic inflammatory and allergic lung disease. / Hizawa, N.; Kawaguchi, M.; Huang, S. K.; Nishimura, M.

In: Clinical and Experimental Allergy, Vol. 36, No. 9, 01.09.2006, p. 1109-1114.

Research output: Contribution to journalReview article

Hizawa, N. ; Kawaguchi, M. ; Huang, S. K. ; Nishimura, M. / Role of interleukin-17F in chronic inflammatory and allergic lung disease. In: Clinical and Experimental Allergy. 2006 ; Vol. 36, No. 9. pp. 1109-1114.
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