Role of interleukin-17F in asthma

Mio Kawaguchi, Fumio Kokubu, Junichi Fujita, Shau Ku Huang, Nobuyuki Hizawa

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

A new family of cytokines, the interleukin (IL)-17 family, has recently been defined, which reveals unique functions and distinct ligand-receptor signaling systems. This family contains six members, IL-17 (also called IL-17A), IL17B, IL-17C, IL-17D, IL-17E (IL-25) and IL-17F. The IL-17F gene was discovered in 2001, and is located on chromosome 6p12. Notably, among this family, IL-17F has been well characterized both in vitro and in vivo, and has been shown to have a pro-inflammatory role in asthma. IL-17F is clearly expressed in the airway of asthmatics and its expression level is correlated with disease severity. Moreover, a coding region variant (H161R) of the IL-17F gene is inversely associated with asthma and encodes an antagonist for the wild-type IL-17F. IL-17F is able to induce several cytokines, chemokines and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts and eosinophils. IL-17F utilizes IL-17RA and IL-17RC as its receptors, and activates the MAP kinase related pathway. IL-17F is derived from several cell types such as Th17 cells, mast cells and basophils, and shows a wide tissue expression pattern including lung. Overexpression of IL-17F gene in the airway of mice is associated with airway neutrophilia, the induction of many cytokines, an increase in airway hyperreactivity, and mucus hypersecretion. Hence, IL-17F may have a crucial role in allergic airway inflammation, and have important therapeutic implications in asthma.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalInflammation and Allergy - Drug Targets
Volume8
Issue number5
DOIs
Publication statusPublished - Jan 1 2009
Externally publishedYes

Fingerprint

Interleukin-17
Asthma
Interleukins
Cytokines
Interleukin-27
Genes
Th17 Cells
Basophils
Mucus

Keywords

  • Asthma
  • IL-17 family
  • IL-17A
  • IL-17F

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Role of interleukin-17F in asthma. / Kawaguchi, Mio; Kokubu, Fumio; Fujita, Junichi; Huang, Shau Ku; Hizawa, Nobuyuki.

In: Inflammation and Allergy - Drug Targets, Vol. 8, No. 5, 01.01.2009, p. 383-389.

Research output: Contribution to journalReview article

Kawaguchi, M, Kokubu, F, Fujita, J, Huang, SK & Hizawa, N 2009, 'Role of interleukin-17F in asthma', Inflammation and Allergy - Drug Targets, vol. 8, no. 5, pp. 383-389. https://doi.org/10.2174/1871528110908050383
Kawaguchi, Mio ; Kokubu, Fumio ; Fujita, Junichi ; Huang, Shau Ku ; Hizawa, Nobuyuki. / Role of interleukin-17F in asthma. In: Inflammation and Allergy - Drug Targets. 2009 ; Vol. 8, No. 5. pp. 383-389.
@article{621b27d63ff744ce9eace7d89f94c411,
title = "Role of interleukin-17F in asthma",
abstract = "A new family of cytokines, the interleukin (IL)-17 family, has recently been defined, which reveals unique functions and distinct ligand-receptor signaling systems. This family contains six members, IL-17 (also called IL-17A), IL17B, IL-17C, IL-17D, IL-17E (IL-25) and IL-17F. The IL-17F gene was discovered in 2001, and is located on chromosome 6p12. Notably, among this family, IL-17F has been well characterized both in vitro and in vivo, and has been shown to have a pro-inflammatory role in asthma. IL-17F is clearly expressed in the airway of asthmatics and its expression level is correlated with disease severity. Moreover, a coding region variant (H161R) of the IL-17F gene is inversely associated with asthma and encodes an antagonist for the wild-type IL-17F. IL-17F is able to induce several cytokines, chemokines and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts and eosinophils. IL-17F utilizes IL-17RA and IL-17RC as its receptors, and activates the MAP kinase related pathway. IL-17F is derived from several cell types such as Th17 cells, mast cells and basophils, and shows a wide tissue expression pattern including lung. Overexpression of IL-17F gene in the airway of mice is associated with airway neutrophilia, the induction of many cytokines, an increase in airway hyperreactivity, and mucus hypersecretion. Hence, IL-17F may have a crucial role in allergic airway inflammation, and have important therapeutic implications in asthma.",
keywords = "Asthma, IL-17 family, IL-17A, IL-17F",
author = "Mio Kawaguchi and Fumio Kokubu and Junichi Fujita and Huang, {Shau Ku} and Nobuyuki Hizawa",
year = "2009",
month = "1",
day = "1",
doi = "10.2174/1871528110908050383",
language = "English",
volume = "8",
pages = "383--389",
journal = "Current Drug Targets: Inflammation and Allergy",
issn = "1871-5281",
publisher = "Bentham Science Publishers B.V.",
number = "5",

}

TY - JOUR

T1 - Role of interleukin-17F in asthma

AU - Kawaguchi, Mio

AU - Kokubu, Fumio

AU - Fujita, Junichi

AU - Huang, Shau Ku

AU - Hizawa, Nobuyuki

PY - 2009/1/1

Y1 - 2009/1/1

N2 - A new family of cytokines, the interleukin (IL)-17 family, has recently been defined, which reveals unique functions and distinct ligand-receptor signaling systems. This family contains six members, IL-17 (also called IL-17A), IL17B, IL-17C, IL-17D, IL-17E (IL-25) and IL-17F. The IL-17F gene was discovered in 2001, and is located on chromosome 6p12. Notably, among this family, IL-17F has been well characterized both in vitro and in vivo, and has been shown to have a pro-inflammatory role in asthma. IL-17F is clearly expressed in the airway of asthmatics and its expression level is correlated with disease severity. Moreover, a coding region variant (H161R) of the IL-17F gene is inversely associated with asthma and encodes an antagonist for the wild-type IL-17F. IL-17F is able to induce several cytokines, chemokines and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts and eosinophils. IL-17F utilizes IL-17RA and IL-17RC as its receptors, and activates the MAP kinase related pathway. IL-17F is derived from several cell types such as Th17 cells, mast cells and basophils, and shows a wide tissue expression pattern including lung. Overexpression of IL-17F gene in the airway of mice is associated with airway neutrophilia, the induction of many cytokines, an increase in airway hyperreactivity, and mucus hypersecretion. Hence, IL-17F may have a crucial role in allergic airway inflammation, and have important therapeutic implications in asthma.

AB - A new family of cytokines, the interleukin (IL)-17 family, has recently been defined, which reveals unique functions and distinct ligand-receptor signaling systems. This family contains six members, IL-17 (also called IL-17A), IL17B, IL-17C, IL-17D, IL-17E (IL-25) and IL-17F. The IL-17F gene was discovered in 2001, and is located on chromosome 6p12. Notably, among this family, IL-17F has been well characterized both in vitro and in vivo, and has been shown to have a pro-inflammatory role in asthma. IL-17F is clearly expressed in the airway of asthmatics and its expression level is correlated with disease severity. Moreover, a coding region variant (H161R) of the IL-17F gene is inversely associated with asthma and encodes an antagonist for the wild-type IL-17F. IL-17F is able to induce several cytokines, chemokines and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts and eosinophils. IL-17F utilizes IL-17RA and IL-17RC as its receptors, and activates the MAP kinase related pathway. IL-17F is derived from several cell types such as Th17 cells, mast cells and basophils, and shows a wide tissue expression pattern including lung. Overexpression of IL-17F gene in the airway of mice is associated with airway neutrophilia, the induction of many cytokines, an increase in airway hyperreactivity, and mucus hypersecretion. Hence, IL-17F may have a crucial role in allergic airway inflammation, and have important therapeutic implications in asthma.

KW - Asthma

KW - IL-17 family

KW - IL-17A

KW - IL-17F

UR - http://www.scopus.com/inward/record.url?scp=74849107906&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74849107906&partnerID=8YFLogxK

U2 - 10.2174/1871528110908050383

DO - 10.2174/1871528110908050383

M3 - Review article

VL - 8

SP - 383

EP - 389

JO - Current Drug Targets: Inflammation and Allergy

JF - Current Drug Targets: Inflammation and Allergy

SN - 1871-5281

IS - 5

ER -