Role of IL-17F in the pathogenesis of psoriasis

Masayuki Nakajima, Mio Kawaguchi, Hideaki Watanabe, Yuko Morishima, Shau Ku Huang, Hiroaki Satoh, Nobuyuki Hizawa

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Psoriasis is a complex autoimmune inflammatory disease with a genetic basis. The increased expression of IL-17F gene and protein is observed in the lesional skins of psoriatic patients. We and other groups discovered human IL-17F gene that shows the highest homology with IL-17A. IL-17F induces various inflammatory molecules, such as IL-6 and IL-8. IL-17F is mainly derived from Th17, Tc17 and ILC3 cells, and induces CCL20 expression, resulting in the recruitment of additional IL-17F-producing cells to enhance skin inflammation via CCR6. The receptor for IL-17F is the heterodimeric complex of IL-17RA and IL-17RC, and several signaling pathways have been identified. Injection with IL-17F in mice revealed marked neutrophilia in dermis, and its infiltration was significantly inhibited by anti-IL-8 antibody. Sequence variants of the IL-17F gene are associated with response to treatments, and a variant (rs763780) of IL-17F encodes an antagonist for the wild-type IL-17F. Hence, IL-17F may play a pivotal role in the pathogenesis of psoriasis, and may provide a promising therapeutic target for development of novel strategies.

Original languageEnglish
Pages (from-to)112-117
Number of pages6
JournalCurrent Immunology Reviews
Volume12
Issue number2
DOIs
Publication statusPublished - Aug 1 2016
Externally publishedYes

Fingerprint

Interleukin-17
Psoriasis
Interleukin-8
Skin
Dermis
Genes
Autoimmune Diseases
Interleukin-6

Keywords

  • IL-17 cytokine family
  • IL-17F
  • Psoriasis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Nakajima, M., Kawaguchi, M., Watanabe, H., Morishima, Y., Huang, S. K., Satoh, H., & Hizawa, N. (2016). Role of IL-17F in the pathogenesis of psoriasis. Current Immunology Reviews, 12(2), 112-117. https://doi.org/10.2174/1573395513666161214121923

Role of IL-17F in the pathogenesis of psoriasis. / Nakajima, Masayuki; Kawaguchi, Mio; Watanabe, Hideaki; Morishima, Yuko; Huang, Shau Ku; Satoh, Hiroaki; Hizawa, Nobuyuki.

In: Current Immunology Reviews, Vol. 12, No. 2, 01.08.2016, p. 112-117.

Research output: Contribution to journalReview article

Nakajima, M, Kawaguchi, M, Watanabe, H, Morishima, Y, Huang, SK, Satoh, H & Hizawa, N 2016, 'Role of IL-17F in the pathogenesis of psoriasis', Current Immunology Reviews, vol. 12, no. 2, pp. 112-117. https://doi.org/10.2174/1573395513666161214121923
Nakajima M, Kawaguchi M, Watanabe H, Morishima Y, Huang SK, Satoh H et al. Role of IL-17F in the pathogenesis of psoriasis. Current Immunology Reviews. 2016 Aug 1;12(2):112-117. https://doi.org/10.2174/1573395513666161214121923
Nakajima, Masayuki ; Kawaguchi, Mio ; Watanabe, Hideaki ; Morishima, Yuko ; Huang, Shau Ku ; Satoh, Hiroaki ; Hizawa, Nobuyuki. / Role of IL-17F in the pathogenesis of psoriasis. In: Current Immunology Reviews. 2016 ; Vol. 12, No. 2. pp. 112-117.
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