Role of IL-17F in the pathogenesis of psoriasis

Masayuki Nakajima, Mio Kawaguchi, Hideaki Watanabe, Yuko Morishima, Shau Ku Huang, Hiroaki Satoh, Nobuyuki Hizawa

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Psoriasis is a complex autoimmune inflammatory disease with a genetic basis. The increased expression of IL-17F gene and protein is observed in the lesional skins of psoriatic patients. We and other groups discovered human IL-17F gene that shows the highest homology with IL-17A. IL-17F induces various inflammatory molecules, such as IL-6 and IL-8. IL-17F is mainly derived from Th17, Tc17 and ILC3 cells, and induces CCL20 expression, resulting in the recruitment of additional IL-17F-producing cells to enhance skin inflammation via CCR6. The receptor for IL-17F is the heterodimeric complex of IL-17RA and IL-17RC, and several signaling pathways have been identified. Injection with IL-17F in mice revealed marked neutrophilia in dermis, and its infiltration was significantly inhibited by anti-IL-8 antibody. Sequence variants of the IL-17F gene are associated with response to treatments, and a variant (rs763780) of IL-17F encodes an antagonist for the wild-type IL-17F. Hence, IL-17F may play a pivotal role in the pathogenesis of psoriasis, and may provide a promising therapeutic target for development of novel strategies.

Original languageEnglish
Pages (from-to)112-117
Number of pages6
JournalCurrent Immunology Reviews
Volume12
Issue number2
DOIs
Publication statusPublished - Aug 1 2016
Externally publishedYes

Keywords

  • IL-17 cytokine family
  • IL-17F
  • Psoriasis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Nakajima, M., Kawaguchi, M., Watanabe, H., Morishima, Y., Huang, S. K., Satoh, H., & Hizawa, N. (2016). Role of IL-17F in the pathogenesis of psoriasis. Current Immunology Reviews, 12(2), 112-117. https://doi.org/10.2174/1573395513666161214121923