Role of genotype and precore/basal core promoter mutations of hepatitis B virus in patients with chronic hepatitis B with acute exacerbation

Wei Lun Tsai, Gin Ho Lo, Ping I. Hsu, Kwok Hung Lai, Chiun Ku Lin, Hoi Hung Chan, Wen Chi Chen, Jin Shiung Cheng, Yung Ching Liu, Tsi Shu Huang, Luo Ping Ger, Hsi Hsun Lin

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22 Citations (Scopus)

Abstract

Objctive. The results of long-term, follow-up studies show that the severity and frequency of acute exacerbation of chronic hepatitis B virus (HBV) are associated with the development of liver cirrhosis in chronic HBV infection. The aim of this study was to investigate the relationship between virological factors of HBV and the severity of acute exacerbation. Material and methods. Fifty-one chronic hepatitis B patients with symptomatic acute exacerbation without antiviral therapy were enrolled in the study. Genotype of HBV was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Precore (A1896) and basal core promoter (BCP) mutations (T1762 & A1764) were determined by PCR and direct sequencing. Results. Thirty-nine patients had genotype B, 11 patients had genotype C, and 1 patient had an unclassified genotype. Thirty-two patients had precore mutation and 24 patients had BCP mutation. After adjusting for age, gender, aspartate aminotransferase (ASAT) level, albumin level, and platelet count by multiple logistic regression test, precore mutation had a protective effect on the occurrence of hepatic decompensation (p=0.046), and genotype and BCP mutations were not associated with the occurrence of hepatic decompensation. Conclusions. HBV precore mutation may confer less severe liver disease during acute exacerbation of chronic HBV. Genotype and BCP mutations did not have a significant association with the occurrence of hepatic decompensation.

Original languageEnglish
Pages (from-to)196-201
Number of pages6
JournalScandinavian Journal of Gastroenterology
Volume43
Issue number2
DOIs
Publication statusPublished - 2008
Externally publishedYes

Keywords

  • Acute exacerbation
  • Basal core promoter mutation
  • Genotype
  • Hepatitis B
  • Precore mutation

ASJC Scopus subject areas

  • Gastroenterology

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  • Cite this

    Tsai, W. L., Lo, G. H., Hsu, P. I., Lai, K. H., Lin, C. K., Chan, H. H., Chen, W. C., Cheng, J. S., Liu, Y. C., Huang, T. S., Ger, L. P., & Lin, H. H. (2008). Role of genotype and precore/basal core promoter mutations of hepatitis B virus in patients with chronic hepatitis B with acute exacerbation. Scandinavian Journal of Gastroenterology, 43(2), 196-201. https://doi.org/10.1080/00365520701745693