Role of genotype and precore/basal core promoter mutations of hepatitis B virus in patients with chronic hepatitis B with acute exacerbation

Wei Lun Tsai, Gin Ho Lo, Ping I. Hsu, Kwok Hung Lai, Chiun Ku Lin, Hoi Hung Chan, Wen Chi Chen, Jin Shiung Cheng, Yung Ching Liu, Tsi Shu Huang, Luo Ping Ger, Hsi Hsun Lin

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objctive. The results of long-term, follow-up studies show that the severity and frequency of acute exacerbation of chronic hepatitis B virus (HBV) are associated with the development of liver cirrhosis in chronic HBV infection. The aim of this study was to investigate the relationship between virological factors of HBV and the severity of acute exacerbation. Material and methods. Fifty-one chronic hepatitis B patients with symptomatic acute exacerbation without antiviral therapy were enrolled in the study. Genotype of HBV was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Precore (A1896) and basal core promoter (BCP) mutations (T1762 & A1764) were determined by PCR and direct sequencing. Results. Thirty-nine patients had genotype B, 11 patients had genotype C, and 1 patient had an unclassified genotype. Thirty-two patients had precore mutation and 24 patients had BCP mutation. After adjusting for age, gender, aspartate aminotransferase (ASAT) level, albumin level, and platelet count by multiple logistic regression test, precore mutation had a protective effect on the occurrence of hepatic decompensation (p=0.046), and genotype and BCP mutations were not associated with the occurrence of hepatic decompensation. Conclusions. HBV precore mutation may confer less severe liver disease during acute exacerbation of chronic HBV. Genotype and BCP mutations did not have a significant association with the occurrence of hepatic decompensation.

Original languageEnglish
Pages (from-to)196-201
Number of pages6
JournalScandinavian Journal of Gastroenterology
Volume43
Issue number2
DOIs
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Chronic Hepatitis B
Hepatitis B virus
Genotype
Mutation
Liver
Polymerase Chain Reaction
Virus Diseases
Aspartate Aminotransferases
Platelet Count
Restriction Fragment Length Polymorphisms
Liver Cirrhosis
Antiviral Agents
Liver Diseases
Albumins
Logistic Models

Keywords

  • Acute exacerbation
  • Basal core promoter mutation
  • Genotype
  • Hepatitis B
  • Precore mutation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Role of genotype and precore/basal core promoter mutations of hepatitis B virus in patients with chronic hepatitis B with acute exacerbation. / Tsai, Wei Lun; Lo, Gin Ho; Hsu, Ping I.; Lai, Kwok Hung; Lin, Chiun Ku; Chan, Hoi Hung; Chen, Wen Chi; Cheng, Jin Shiung; Liu, Yung Ching; Huang, Tsi Shu; Ger, Luo Ping; Lin, Hsi Hsun.

In: Scandinavian Journal of Gastroenterology, Vol. 43, No. 2, 2008, p. 196-201.

Research output: Contribution to journalArticle

Tsai, Wei Lun ; Lo, Gin Ho ; Hsu, Ping I. ; Lai, Kwok Hung ; Lin, Chiun Ku ; Chan, Hoi Hung ; Chen, Wen Chi ; Cheng, Jin Shiung ; Liu, Yung Ching ; Huang, Tsi Shu ; Ger, Luo Ping ; Lin, Hsi Hsun. / Role of genotype and precore/basal core promoter mutations of hepatitis B virus in patients with chronic hepatitis B with acute exacerbation. In: Scandinavian Journal of Gastroenterology. 2008 ; Vol. 43, No. 2. pp. 196-201.
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T1 - Role of genotype and precore/basal core promoter mutations of hepatitis B virus in patients with chronic hepatitis B with acute exacerbation

AU - Tsai, Wei Lun

AU - Lo, Gin Ho

AU - Hsu, Ping I.

AU - Lai, Kwok Hung

AU - Lin, Chiun Ku

AU - Chan, Hoi Hung

AU - Chen, Wen Chi

AU - Cheng, Jin Shiung

AU - Liu, Yung Ching

AU - Huang, Tsi Shu

AU - Ger, Luo Ping

AU - Lin, Hsi Hsun

PY - 2008

Y1 - 2008

N2 - Objctive. The results of long-term, follow-up studies show that the severity and frequency of acute exacerbation of chronic hepatitis B virus (HBV) are associated with the development of liver cirrhosis in chronic HBV infection. The aim of this study was to investigate the relationship between virological factors of HBV and the severity of acute exacerbation. Material and methods. Fifty-one chronic hepatitis B patients with symptomatic acute exacerbation without antiviral therapy were enrolled in the study. Genotype of HBV was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Precore (A1896) and basal core promoter (BCP) mutations (T1762 & A1764) were determined by PCR and direct sequencing. Results. Thirty-nine patients had genotype B, 11 patients had genotype C, and 1 patient had an unclassified genotype. Thirty-two patients had precore mutation and 24 patients had BCP mutation. After adjusting for age, gender, aspartate aminotransferase (ASAT) level, albumin level, and platelet count by multiple logistic regression test, precore mutation had a protective effect on the occurrence of hepatic decompensation (p=0.046), and genotype and BCP mutations were not associated with the occurrence of hepatic decompensation. Conclusions. HBV precore mutation may confer less severe liver disease during acute exacerbation of chronic HBV. Genotype and BCP mutations did not have a significant association with the occurrence of hepatic decompensation.

AB - Objctive. The results of long-term, follow-up studies show that the severity and frequency of acute exacerbation of chronic hepatitis B virus (HBV) are associated with the development of liver cirrhosis in chronic HBV infection. The aim of this study was to investigate the relationship between virological factors of HBV and the severity of acute exacerbation. Material and methods. Fifty-one chronic hepatitis B patients with symptomatic acute exacerbation without antiviral therapy were enrolled in the study. Genotype of HBV was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Precore (A1896) and basal core promoter (BCP) mutations (T1762 & A1764) were determined by PCR and direct sequencing. Results. Thirty-nine patients had genotype B, 11 patients had genotype C, and 1 patient had an unclassified genotype. Thirty-two patients had precore mutation and 24 patients had BCP mutation. After adjusting for age, gender, aspartate aminotransferase (ASAT) level, albumin level, and platelet count by multiple logistic regression test, precore mutation had a protective effect on the occurrence of hepatic decompensation (p=0.046), and genotype and BCP mutations were not associated with the occurrence of hepatic decompensation. Conclusions. HBV precore mutation may confer less severe liver disease during acute exacerbation of chronic HBV. Genotype and BCP mutations did not have a significant association with the occurrence of hepatic decompensation.

KW - Acute exacerbation

KW - Basal core promoter mutation

KW - Genotype

KW - Hepatitis B

KW - Precore mutation

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