Role of Demodex mite infestation in rosacea: A systematic review and meta-analysis

Yin Shuo Chang, Yu-Chen Huang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background The reported prevalence and degrees of Demodex mite infestation in rosacea vary widely. Objective We sought to conduct an evidence-based meta-analysis of the prevalence and degrees of Demodex mite infestation in patients with rosacea. Methods Systematic literature review and meta-analysis were conducted. Odds ratios for prevalence of infestation and standardized mean difference (SMD) for Demodex density in patients with rosacea were pooled. Subgroup analysis for type of rosacea, control group, and sampling and examination methods were also performed. Results Twenty-three case-control studies included 1513 patients with rosacea. Compared with the control patients, patients with rosacea were more likely to be infested by Demodex mites [odds ratio, 9.039; 95% confidence interval (CI), 4.827-16.925] and had significantly higher Demodex density (SMD, 1.617; 95% CI, 1.090-2.145). Both erythematotelangiectatic rosacea (SMD, 2.686; 95% CI, 1.256-4.116) and papulopustular rosacea (SMD, 2.804; 95% CI, 1.464-4.145) had significantly higher Demodex density than did healthy control patients. Limitations Interstudy variability was high, and a causal relationship could not be established by case-control studies. Conclusions Patients with rosacea had significantly higher prevalence and degrees of Demodex mite infestation than did control patients. Demodex mites may play a role in both erythematotelangiectatic rosacea and papulopustular rosacea.

Original languageEnglish
Pages (from-to)441-447.e6
JournalJournal of the American Academy of Dermatology
Volume77
Issue number3
DOIs
Publication statusPublished - Sep 1 2017

Fingerprint

Mite Infestations
Rosacea
Meta-Analysis
Confidence Intervals
Mites
Case-Control Studies
Odds Ratio
Tick Control

Keywords

  • Demodex mites
  • erythematotelangiectatic rosacea
  • meta-analysis
  • papulopustular rosacea
  • rosacea
  • standardized superficial skin biopsy

ASJC Scopus subject areas

  • Dermatology

Cite this

Role of Demodex mite infestation in rosacea : A systematic review and meta-analysis. / Chang, Yin Shuo; Huang, Yu-Chen.

In: Journal of the American Academy of Dermatology, Vol. 77, No. 3, 01.09.2017, p. 441-447.e6.

Research output: Contribution to journalArticle

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abstract = "Background The reported prevalence and degrees of Demodex mite infestation in rosacea vary widely. Objective We sought to conduct an evidence-based meta-analysis of the prevalence and degrees of Demodex mite infestation in patients with rosacea. Methods Systematic literature review and meta-analysis were conducted. Odds ratios for prevalence of infestation and standardized mean difference (SMD) for Demodex density in patients with rosacea were pooled. Subgroup analysis for type of rosacea, control group, and sampling and examination methods were also performed. Results Twenty-three case-control studies included 1513 patients with rosacea. Compared with the control patients, patients with rosacea were more likely to be infested by Demodex mites [odds ratio, 9.039; 95{\%} confidence interval (CI), 4.827-16.925] and had significantly higher Demodex density (SMD, 1.617; 95{\%} CI, 1.090-2.145). Both erythematotelangiectatic rosacea (SMD, 2.686; 95{\%} CI, 1.256-4.116) and papulopustular rosacea (SMD, 2.804; 95{\%} CI, 1.464-4.145) had significantly higher Demodex density than did healthy control patients. Limitations Interstudy variability was high, and a causal relationship could not be established by case-control studies. Conclusions Patients with rosacea had significantly higher prevalence and degrees of Demodex mite infestation than did control patients. Demodex mites may play a role in both erythematotelangiectatic rosacea and papulopustular rosacea.",
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N2 - Background The reported prevalence and degrees of Demodex mite infestation in rosacea vary widely. Objective We sought to conduct an evidence-based meta-analysis of the prevalence and degrees of Demodex mite infestation in patients with rosacea. Methods Systematic literature review and meta-analysis were conducted. Odds ratios for prevalence of infestation and standardized mean difference (SMD) for Demodex density in patients with rosacea were pooled. Subgroup analysis for type of rosacea, control group, and sampling and examination methods were also performed. Results Twenty-three case-control studies included 1513 patients with rosacea. Compared with the control patients, patients with rosacea were more likely to be infested by Demodex mites [odds ratio, 9.039; 95% confidence interval (CI), 4.827-16.925] and had significantly higher Demodex density (SMD, 1.617; 95% CI, 1.090-2.145). Both erythematotelangiectatic rosacea (SMD, 2.686; 95% CI, 1.256-4.116) and papulopustular rosacea (SMD, 2.804; 95% CI, 1.464-4.145) had significantly higher Demodex density than did healthy control patients. Limitations Interstudy variability was high, and a causal relationship could not be established by case-control studies. Conclusions Patients with rosacea had significantly higher prevalence and degrees of Demodex mite infestation than did control patients. Demodex mites may play a role in both erythematotelangiectatic rosacea and papulopustular rosacea.

AB - Background The reported prevalence and degrees of Demodex mite infestation in rosacea vary widely. Objective We sought to conduct an evidence-based meta-analysis of the prevalence and degrees of Demodex mite infestation in patients with rosacea. Methods Systematic literature review and meta-analysis were conducted. Odds ratios for prevalence of infestation and standardized mean difference (SMD) for Demodex density in patients with rosacea were pooled. Subgroup analysis for type of rosacea, control group, and sampling and examination methods were also performed. Results Twenty-three case-control studies included 1513 patients with rosacea. Compared with the control patients, patients with rosacea were more likely to be infested by Demodex mites [odds ratio, 9.039; 95% confidence interval (CI), 4.827-16.925] and had significantly higher Demodex density (SMD, 1.617; 95% CI, 1.090-2.145). Both erythematotelangiectatic rosacea (SMD, 2.686; 95% CI, 1.256-4.116) and papulopustular rosacea (SMD, 2.804; 95% CI, 1.464-4.145) had significantly higher Demodex density than did healthy control patients. Limitations Interstudy variability was high, and a causal relationship could not be established by case-control studies. Conclusions Patients with rosacea had significantly higher prevalence and degrees of Demodex mite infestation than did control patients. Demodex mites may play a role in both erythematotelangiectatic rosacea and papulopustular rosacea.

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