Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity

Wan Jr Syu, Woan Ruoh Lee, Bin Du, Qian Chun Yu, Max Essex, Tun Hou Lee

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All animal retroviruses whose nucleotide sequences have been determined contain two or three closely spaced cysteine residues in the extracellular domain of the env-encoded transmembrane protein. Using human immunodeficiency virus type 1 gp41 as a working model, the functional significance of these highly conserved cysteines was investigated. We report here that substituting the two conserved cysteine residues in this domain of gp41 with glycine residues resulted in the loss of viral infectivity, which could be attributed to severe impairment in the processing of gp160 precursor to gp120.

Original languageEnglish
Pages (from-to)6349-6352
Number of pages4
JournalJournal of Virology
Issue number11
Publication statusPublished - Nov 1991
Externally publishedYes


ASJC Scopus subject areas

  • Immunology

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