Role of calmodulin/protein kinase C in interferon production by poly(rI) · poly(rC) in primed human cell cultures

H. Y. Lin, H. R. Thacore

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Human cells treated with trifluoperazine (TFP) or K252a prior to and/or during priming with human interferon-α (HuIFN-α) produce significantly more IFN on induction with poly(rI) · poly(rC) than primed cells in the absence of the drug. Results suggest that calmodulin/protein kinase activity may be involved in priming activity of HuIFN-α.

Original languageEnglish
Pages (from-to)375-378
Number of pages4
JournalJournal of Interferon Research
Issue number4
Publication statusPublished - 1990
Externally publishedYes


ASJC Scopus subject areas

  • Immunology
  • Virology

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