Rivaroxaban modulates electrical and mechanical characteristics of left atrium

Chien Jung Chang, Yao Chang Chen, Yung Kuo Lin, Jen Hung Huang, Shih Ann Chen, Yi Jen Chen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Rivaroxaban reduces stroke in patients with atrial fibrillation (AF). Left atrium (LA) plays a critical role in the pathophysiology of AF. However, the electromechanical effects of rivaroxaban on LA are not clear. Results: Conventional microelectrodes and a whole-cell patch-clamp were used to record the action potentials (APs) and ionic currents in rabbit LA preparations and isolated single LA cardiomyocytes before and after the administration of rivaroxaban. Rivaroxaban (10, 30, 100, and 300 nM) concentration-dependently reduced LA (n = 7) AP durations at 90% repolarization (APD§ssub§ 90§esub§) from 76 ± 2 to 79 ± 3, 67 ± 4 (P <0.05, vs. control), 59 ± 5, (P <0.01, vs. control), and 56 ± 4 ms (P <0.005, vs. control), respectively. Rivaroxaban (10, 30, 100, and 300 nM) concentration-dependently increased the LA (n = 7) diastolic tension by 351 ± 69 (P <0.05, vs. control), 563 ± 136 (P <0.05, vs. control), 582 ± 119 (P <0.05, vs. control), and 603 ± 108 mg (P <0.005, vs. control), respectively, but did not change LA contractility. In the presence of L-NAME (100 μM) and indomethacin (10 μM), additional rivaroxaban (300 nM) treatment did not significantly further increase the LA (n = 7) diastolic tension, but shortened the APD§ssub§90§esub§ from 73 ± 2 to 60 ± 6 ms (P <0.05, vs. control). Rivaroxaban (100 nM) increased the L-type calcium current and ultra-rapid delayed rectifier potassium current, but did not change the transient outward potassium current in isolated LA cardiomyocytes. Conclusions: Rivaroxaban modulates LA electrical and mechanical characteristics with direct ionic current effects.

Original languageEnglish
Article number17
JournalJournal of Biomedical Science
Volume20
Issue number1
DOIs
Publication statusPublished - 2013

Keywords

  • Atrial fibrillation
  • Cyclooxygenase
  • Factor Xa
  • Nitric oxide synthase
  • Rivaroxaban

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Cell Biology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Pharmacology (medical)

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