Risk stratification and clinical outcomes in patients with acute pulmonary embolism

Chi Ming Huang, Yen Chung Lin, Yenn Jiang Lin, Shih Lin Chang, Li Wei Lo, Yu Feng Hu, Chern En Chiang, Kang Ling Wang, Shih Ann Chen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objectives: Pulmonary embolism is a common disease associated with a high mortality rate. The risk assessment and appropriate treatment selection of patients with acute pulmonary embolism remains a challenge. Design and methods: This single center cohort study included a total of 150 patients (96 male, age = 71. ±. 15 years) with acute pulmonary embolism confirmed by spiral-computed tomography or magnetic resonance image. The prognostic performance of the clinical characteristics and laboratory values were investigated to predict the in-hospital hemodynamically instable events and 30-day all-cause mortality. Results: The rate of in-hospital hemodynamic instability and 30-day all-cause mortality was 21% and 12%, respectively. A multivariate Cox regression analysis demonstrated that a heart rate≥ 110bpm (odd ratio 4.26 [95% CI 1.42-12.77]), chronic pulmonary disease (6.47 [1.99-21.04]), WBC≥11,000mm 3 (3.78 [1.32-10.82]), and D-dimer level≥4.0μg/mL (3.68 [1.01-13.43]) independently predicted the 30-day fatal outcome. A Kaplan-Meier survival analysis showed that the categorization based on the number of risk factors was significantly associated with the likelihood of 30-day all-cause mortality (P

Original languageEnglish
Pages (from-to)1110-1115
Number of pages6
JournalClinical Biochemistry
Volume44
Issue number13
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Hemodynamic instability
  • Mortality
  • Prognosis
  • Pulmonary embolism
  • Risk stratification

ASJC Scopus subject areas

  • Clinical Biochemistry

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  • Cite this

    Huang, C. M., Lin, Y. C., Lin, Y. J., Chang, S. L., Lo, L. W., Hu, Y. F., Chiang, C. E., Wang, K. L., & Chen, S. A. (2011). Risk stratification and clinical outcomes in patients with acute pulmonary embolism. Clinical Biochemistry, 44(13), 1110-1115. https://doi.org/10.1016/j.clinbiochem.2011.06.077