Risk profile of patients with poor-grade aneurysmal subarachnoid hemorrhage using early perfusion computed tomography

Fon Yih Tsuang, Jo Yu Chen, Chung Wei Lee, Chien Hsun Li, Jing Er Lee, Dar Ming Lai, Fu Chang Hu, Yong Kwang Tu, Sung Tsang Hsieh, Kuo Chuan Wang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: To determine whether perfusion computed tomography (CT) is useful for identifying patients with poor-grade subarachnoid hemorrhage (SAH) with reversible etiologies and whether early obliteration in patients with poor-grade aneurysmal SAH leads to favorable outcomes. Methods: Patients with new-onset aneurysmal SAH in World Federation of Neurological Surgeons (WFNS) grade IV or V neurologic condition who had perfusion CT performed at admission were eligible for the study. The study retrospectively enrolled 38 patients seen between January 2007 and July 2009. The decision to perform an early obliteration was made by the family after a discussion with the neurosurgeons, neurointensivists, and interventional radiologists. The functional outcomes were correlated with the Glasgow Outcome Scale (GOS) at 6 months, and quantitative perfusion CT data were collected. Results: This study included 10 (26%) grade IV and 28 (74%) grade V patients. Favorable outcomes occurred in 19 (50%) patients, and 11 (29%) patients died. After a multivariate logistic regression analysis of the parameters, older age (odds ratio 1.104, P = 0.0317), bilateral prolonged mean transient time (MTT) at the thalami (odds ratio 4.155, P = 0.0362), and early obliteration (odds ratio 0.098, P = 0.003) were predictive of poor outcome. Conclusions: Early bilateral prolonged MTT at the thalami and old age are associated with a poor outcome. Early obliteration benefits a significant portion of SAH patients. Crown

Original languageEnglish
Pages (from-to)455-461
Number of pages7
JournalWorld Neurosurgery
Volume78
Issue number5
DOIs
Publication statusPublished - Nov 1 2012
Externally publishedYes

Fingerprint

Subarachnoid Hemorrhage
Perfusion
Tomography
Odds Ratio
Thalamus
Glasgow Outcome Scale
Crowns
Nervous System
Logistic Models
Regression Analysis

Keywords

  • Aneurysm
  • Perfusion computed tomography
  • Subarachnoid hemorrhage

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Tsuang, F. Y., Chen, J. Y., Lee, C. W., Li, C. H., Lee, J. E., Lai, D. M., ... Wang, K. C. (2012). Risk profile of patients with poor-grade aneurysmal subarachnoid hemorrhage using early perfusion computed tomography. World Neurosurgery, 78(5), 455-461. https://doi.org/10.1016/j.wneu.2011.12.004

Risk profile of patients with poor-grade aneurysmal subarachnoid hemorrhage using early perfusion computed tomography. / Tsuang, Fon Yih; Chen, Jo Yu; Lee, Chung Wei; Li, Chien Hsun; Lee, Jing Er; Lai, Dar Ming; Hu, Fu Chang; Tu, Yong Kwang; Hsieh, Sung Tsang; Wang, Kuo Chuan.

In: World Neurosurgery, Vol. 78, No. 5, 01.11.2012, p. 455-461.

Research output: Contribution to journalArticle

Tsuang, FY, Chen, JY, Lee, CW, Li, CH, Lee, JE, Lai, DM, Hu, FC, Tu, YK, Hsieh, ST & Wang, KC 2012, 'Risk profile of patients with poor-grade aneurysmal subarachnoid hemorrhage using early perfusion computed tomography', World Neurosurgery, vol. 78, no. 5, pp. 455-461. https://doi.org/10.1016/j.wneu.2011.12.004
Tsuang, Fon Yih ; Chen, Jo Yu ; Lee, Chung Wei ; Li, Chien Hsun ; Lee, Jing Er ; Lai, Dar Ming ; Hu, Fu Chang ; Tu, Yong Kwang ; Hsieh, Sung Tsang ; Wang, Kuo Chuan. / Risk profile of patients with poor-grade aneurysmal subarachnoid hemorrhage using early perfusion computed tomography. In: World Neurosurgery. 2012 ; Vol. 78, No. 5. pp. 455-461.
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AU - Li, Chien Hsun

AU - Lee, Jing Er

AU - Lai, Dar Ming

AU - Hu, Fu Chang

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AU - Hsieh, Sung Tsang

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