Risk prediction for early mortality in patients with newly diagnosed primary CNS lymphoma

Chia Hsin Lin, Ching Fen Yang, Huai Che Yang, Li Yu Fay, Chiu Mei Yeh, Ai Seon Kuan, Hao Yuan Wang, Jyh Pyng Gau, Liang Tsai Hsiao, Tzeon Jye Chiou, Po Min Chen, Yao Chung Liu, Po Shen Ko, Jin Hwang Liu, Chia Jen Liu

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Background: Overall survival of patients with primary CNS lymphoma (PCNSL) has improved since the introduction of immunochemotherapy. However, up to 10–15% of PCNSL patients still die shortly after diagnosis. In the present study, we aimed to investigate the risk factors of early mortality (death within 60 days after diagnosis) in patients with PCNSL. Methods: We included newly diagnosed PCNSL patients in a tertiary medical center in Taiwan between January 1, 2002 and May 31, 2018. Clinical risk factors were collected and compared between PCNSL patients who had and did not have early mortality. Results: A total of 133 consecutive patients with PCNSL were included in this study. Approximately 9.8% of the PCNSL patients had early mortality. In multivariate analysis, age ≥ 80 (adjusted hazard ratio [HR] 3.34, 95% confidence interval [CI] 1.01–11.04, p = 0.048) and involvement of the basal ganglia (adjusted HR 4.85, 95% CI 1.47–15.95, p = 0.009) were identified as independent risk factors of early mortality. Use of MTX-based chemotherapy served as an independent protective factor for early mortality (adjusted HR 0.19, 95% CI 0.05–0.67, p = 0.010). Infection and tumor-associated mass effect contributed most to early mortality. Conclusion: Early mortality is not uncommon in patients with PCNSL. Identification of patients with higher risk may help clinicians with initiating appropriate surveillance and management.

Original languageEnglish
Pages (from-to)3958-3966
Number of pages9
JournalJournal of Cancer
Issue number17
Publication statusPublished - 2019
Externally publishedYes


  • Early mortality
  • Epidemiology
  • Primary CNS lymphoma
  • Prognostic factors

ASJC Scopus subject areas

  • Oncology


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